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hypogonadism/albumin

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Animal model of isolated gonadotropin deficiency. I. Hormonal responses to LHRH immunoneutralization.

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Five intact male mongrel dogs, characterized by an episodic secretory pattern of LH and normal serum testosterone concentrations, were actively immunized against LHRH by subcutaneous injections of 200 micrograms of a LHRH-human serum albumin conjugate at 0, 4, and 8 weeks. After 12 weeks, two dogs

Association between hypogonadism, symptom burden, and survival in male patients with advanced cancer.

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BACKGROUND A high frequency of hypogonadism has been reported in male patients with advanced cancer. The current study was performed to evaluate the association between low testosterone levels, symptom burden, and survival in male patients with cancer. METHODS Of 131 consecutive male patients with

Male hypogonadism associated with advanced cancer: a systematic review.

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Male hypogonadism is commonly diagnosed on the basis of subphysiological concentrations of androgen hormones, and is associated with many symptoms present in advanced cancer. Androgen deficiency might be an important cause of muscle wasting in both cancer cachexia and sarcopenia. We did a systematic

[Late-onset hypogonadism among old and middle-aged males in a rural community of Zhejiang Province].

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OBJECTIVE To investigate the epidemiology of late-onset hypogonadism (LOH) in old and middle-aged males in the rural area of Southern China. METHODS Using the age-stratified sampling method, we conducted a questionnaire investigation on androgen deficiency in aging males (ADAM), aging male symptoms
OBJECTIVE Guidelines recommend serum total testosterone measurement as the initial test to evaluate male hypogonadism, reserving free testosterone assessment for men with suspected sex hormone-binding globulin abnormalities or total testosterone near the lower limit of normal. We determined the

When is bioavailable testosterone a redundant test in the diagnosis of hypogonadism in men?

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OBJECTIVE Total testosterone (TT) is frequently prescribed with an SHBG and/or free or bioavailable testosterone measurement. Our objective was to identify a TT range for which subsequent SHBG measurement/calculation adds no additional clinical information. METHODS Study data were composed of 3955

Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients.

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With the availability of a potential treatment to reverse male hypogonadism (MH), the primary aim of this case series study was to determine independent relationships between this condition and the nutritional, functional, and quality of life characteristics of advanced cancer patients (ACP). Free

Prevalence of hypogonadism in patients with type 2 diabetes mellitus among the Indian population

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Objectives: To determine the prevalence of hypogonadism among Indian men with and without type 2 diabetes mellitus (T2DM) and evaluate its association with various metabolic parameters. Methods:

HIV-associated hypogonadism.

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Hypogonadism in men with HIV disease is an ongoing concern, even among patients whose viral replication is under control and who have normalized CD4+ cell counts. Men with HIV disease may be more prone to a syndrome of "early andropause," marked by dysregulation of the hypothalamic-pituitary axis
OBJECTIVE Testosterone stimulates erythropoiesis and thus glycated hemoglobin (A1C) values may be relatively low in male diabetic patients with hypogonadism. We therefore investigated relationships between serum bioavailable testosterone concentration and the ratio of glycated albumin (GA) to A1C

Current stepwise recommendations for hypogonadism screening in erectile dysfunction are not cost-effective.

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Hypogonadism is a prevalent comorbidity with erectile disfunction (ED) and current guidelines recommend screening for hypogonadism with total testosterone (TT). If low TT is detected, further assessment with LH and SHBG plus albumin are needed to establish an etiology and treatment. Our primary

Laboratory diagnosis of late-onset male hypogonadism andropause.

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OBJECTIVE To evaluate which factors influence the laboratorial diagnosis of late-onset male hypogonadism (LOH). METHODS Total testosterone (TT), SHBG and albumin were measured in 216 men aged 52-84 years. The laboratorial definition of LOH was two values of calculated free testosterone (cFT) <6.5
OBJECTIVE The aim of this study is to compare calculated free testosterone (cFT) and total testosterone (T) in predicting late-onset hypogonadism (LOH) in middle-aged and elderly males. METHODS We surveyed a random sample of 608 males between the ages of 45 and 87 years from Shanghai, China. The

Association of hypogonadism with vitamin D status: the European Male Ageing Study.

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OBJECTIVE Interrelationships between hormones of the hypothalamic-pituitary-testicular (HPT) axis, hypogonadism, vitamin D and seasonality remain poorly defined. We investigated whether HPT axis hormones and hypogonadism are associated with serum levels of 25-hydroxyvitamin D (25(OH)D) in

Hypogonadotropic hypogonadism in nephrotic rats: increased sensitivity to negative feedback effects of testosterone.

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Pituitary-testicular function was examined in adult male rats with aminonucleoside-induced nephrotic syndrome as a model for similar disease in humans. Nephrotic rats developed androgen deficiency, as manifested by decreased prostate and seminal vesicle weights, lower serum total and free
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