hypoprothrombinemias/albumin

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Rescue of prothrombin-deficiency by transgene expression in mice.

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Prothrombin has diverse biological functions in addition to its well established role in blood coagulation. In order to study these functions in more detail mouse model systems are needed. Since deficiency of prothrombin in mice results in partial embryonic lethality and neonatal death, alternative

Hypoprothrombinemia associated with cefmetazole.

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OBJECTIVE To report a case of hypoprothrombinemia associated with the use of cefmetazole sodium, define patients at risk for this adverse effect, and identify options to prevent this problem. METHODS A malnourished patient with endstage renal disease received cefmetazole following a below-the-knee

Transient hypoproteinemia and hypoprothrombinemia in an infant.

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A 7 months old infant with transient hypoproteinemia and hypoprothrombinemia is described. The hypoproteinemia is attributed to protein losing enteropathy, and transient Menetrier's disease is suggested as a possible cause for the protein loss. Assuming that this baby was not vitamin K deficient,

Cefoperazone for empiric therapy in patients with impaired renal function.

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Thirty-five patients with serious infections and impaired renal function were treated empirically with 2 to 8 g of cefoperazone per day. Infections included sepsis in 14, nonbacteremic urinary infections in nine, pneumonia in five, intra-abdominal infection in five, fasciitis in one, and malignant

Prognosis of histological cirrhosis in type 1 autoimmune hepatitis.

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OBJECTIVE Cirrhosis connotes irreversible damage to the liver and shortened life expectancy. The aim of this study was to evaluate the impact of cirrhosis on treatment response and survival in type 1 autoimmune hepatitis. METHODS One hundred twenty-eight patients were evaluated for histological

[Biochemicals markers of risk for mortality in necrotizing fasciitis].

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OBJECTIVE To identify if anemia, hypoalbuminemia, hypocalcemia, elevated values of creatinephosphokinase and hypoprothrombinemia are risk for mortality in necrotizing fasciitis according to the anatomical site and affected surface. METHODS A case and controls study was done in one prospective

Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2.

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Menadione (Vitamin K₃) is an over-the-counter (OTC) drug used in the treatment of abdominal cramps, colitis, diarrhea, hay fever, hemorrahage, hypoprothrombinemia, and joint pains. In this study, we evaluated the protective influence of protocatechuic acid on menadione-induced

Correlation of liver function and morphological abnormalities in mitral stenosis.

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In 50 patients with mitral stenosis in the stage of maximal clinical improvement a correlation between the functional state of liver and the morphological changes was estblished. For this purpose the serum total bilirubin concentration was determined together with the serum total protein, albumin

[Relation of laboratory parameters to complications of liver cirrhosis].

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Liver cirrhosis is characterized with alterations in hepatocytic perfusion, decreasing in number of hepatocytes and with seriously impared synthetic function of liver (hypoalbuminemy, inversion of albumino-globulinic ratio, hypoprothrombinemia). In a group of patients, suffered of liver cirrhosis

Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin.

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Sulfinpyrazone and phenylbutazone cause stereoselective alterations in the metabolic clearance of racemic warfarin in man. To determine if these drugs additionally displace warfarin from its binding sites in vivo free fractions of plasma warfarin were measured by equilibrium dialysis. Single doses

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