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Effectiveness and safety of tolvaptan in liver cirrhosis patients with edema: Interim results of post-marketing surveillance of tolvaptan in liver cirrhosis (START study).

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OBJECTIVE Loop diuretics and spironolactone are used in patients with hepatic edema, but they are sometimes associated with insufficient responses as well as adverse events. Tolvaptan, a vasopressin type 2 receptor antagonist, was approved for hepatic edema in 2013. A large-scale post-marketing

Postoperative usage of tolvaptan in a patient with aortic valve stenosis complicated by Child-Pugh classification B liver cirrhosis and hepatic edema.

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We report the case of an 80-year-old woman with postoperative congestive heart failure (CHF) complicated by Child-Pugh classification B liver cirrhosis and hepatic edema successfully treated with tolvaptan. The patient suffered from liver cirrhosis and underwent partial hepatectomy for a

Pulmonary interstitial edema in experimental cirrhosis of the liver in rats.

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To determine whether interstitial pulmonary edema occurs or not in experimental cirrhotic rats, male Sprague-Dawley rats were given carbon tetrachloride subcutaneously in order to induce liver cirrhosis. The percent lung water content of the cirrhotic rats increased to 79.1 +/- 0.7% compared to 77.4

Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: A randomized, double-blind, placebo-controlled trial.

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OBJECTIVE Liver cirrhosis represents the end stage of any chronic liver disease, and it is associated with hepatic edema such as ascites. Many patients with ascites do not respond to diuretic therapy or require administration of diuretics at high doses that can cause adverse events. This 7-day,

Correlation between changes in bodyweight and changes in ascites volume in liver cirrhosis patients with hepatic edema in short-term diuretic therapy.

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OBJECTIVE Although it is an important treatment challenge to treat ascites with diuretic therapy, no objective markers have been established to assess improvement of ascites. However, change in bodyweight has been used as a marker of change in ascites volume. Thus, we evaluated the relationship

Real-world effectiveness and safety of tolvaptan in liver cirrhosis patients with hepatic edema: results from a post-marketing surveillance study (START study).

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This large-scale post-marketing surveillance study (START study) evaluated the effectiveness and safety of tolvaptan in Japanese liver cirrhosis patients with hepatic edema in real-world clinical settings. Here, we present the final analysis outcomes.A

Clinical significance of small-bowel villous edema in patients with liver cirrhosis-a capsule endoscopy study.

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OBJECTIVE The relationship between the presence of villous edema (VE) in portal hypertensive enteropathy and clinical factors remains unclear. The aim of this study was to reveal the clinical factors related to VE in patients with liver cirrhosis (LC), and investigate the clinical significance of

Analysis of factors predicting the response to tolvaptan in patients with liver cirrhosis and hepatic edema.

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OBJECTIVE This study aimed to clarify the factors predictive of treatment response to tolvaptan (V2-receptor antagonist) for cirrhotic patients with hepatic edema in a real-world setting. METHODS In this retrospective, multicenter study, tolvaptan was orally administered at a dose of 7.5 mg once a

[Furosemide-amiloride combination in the treatment of ascitic-edema in patients with hepatic cirrhosis].

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The combination of furosemide-amiloride was used in the management of fluid retention in 16 cirrhotic patients. The study lasted 60 days. In 15 out of the 16 patients a clinical response was observed, namely increased urinary volumen and reduction of abdominal girth. The body weight was reduced by a

Electrolyte partition in patients with edema of various origins; qualitative and quantitative definition of cations and anions in hepatic cirrhosis.

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Clinical experience with metolazone--a new diuretic--in cases of edema and ascites due to hepatic cirrhosis, C.C.F., and malnutrition.

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[DIURESIS, ELECTROLYTES AND ALDOSTERONE AFTER TRIAMTERENE: FINDINGS IN THE SO-CALLED "REFRACTORY EDEMAS" OF PATIENTS WITH HEART DISEASE AND LIVER CIRRHOSIS].

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[On a renal factor in the pathogenesis of edema of the late stages of cardiac insufficiency and liver cirrhosis].

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[New facts on the metabolism of water and the formation of edemas and ascitis in cirrhosis of the liver].

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[ALTERATIONS IN THE EXCRETION OF ALDOSTERONE AND ELECTROLYTES IN HEPATIC CIRRHOSIS, CONGESTIVE HEART FAILURE AND IDIOPATHIC EDEMAS].

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