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Sida 1 från 35 resultat
[Effect of matrine on mouse hepatitis and tumor necrosis factor production induced by Propionibacterium acnes/lipopolysaccharides].
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The effect of matrine (Mat) on lipopolysaccharides (LPS)-induced fatal hepatitis and tumor necrosis factor (TNF) production in Propionibacterium acnes (PA)-primed mice were studied. Mice were injected i.p. LPS (10 micrograms/mouse) 7 d after i.p. PA (0.5 ml/mouse) to induce fatal hepatitis. After
[Inhibitory effect of matrine on lipopolysacchride-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cells].
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The effect of matrine on the lipopolysacchride (LPS)-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg.L-1 suppressed TNF and IL-6 production from Cal-primed Kupffer cells in the presence of
Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6.
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The matrine-type alkaloid, oxymatrine inhibits hepatitis B virus (HBV) replication but very little is known about these effects in other matrine-type alkaloids, including sophoridine and sophocarpine. Therefore, we compared the in vitro anti-HBV effects of matrine, oxymatrine, sophocarpine, and
Effect of matrine on lipopolysaccharides/D-galactosamine-induced hepatitis and tumor necrosis factor release from macrophages in vitro.
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OBJECTIVE
To study the effects of matrine (Mat) on lipopolysaccharides (LPS)-induced fatal hepatitis in D-galactosamine (D-GalN)-sensitized mice and tumor necrosis factor (TNF) release from peritoneal macrophages (PMO).
METHODS
Mice were pretreated with Mat (10, 50 mg.kg-1, i.p., bid x 3 d), and
Matrine and baicalin inhibit apoptosis induced by Panton-Valentine leukocidin of Staphylococcus aureus in bovine mammary epithelial cells.
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It was previously thought that the Panton-Valentine leukocidin (PVL) toxin of Staphylococcus aureus (S. aureus) was not the main cause of cow mastitis. However, in recent years, detection of the gene encoding PVL has been increasing in dairy cow mastitis, which implies that PVL may be related to
Neuroprotective effect of heat shock protein 60 on matrine-suppressed microglial activation.
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Matrine (MT) is the primary active alkaloid separated from members of the Sophora genus. Previous studies have reported that MT has anti-inflammatory effects in the central nervous system (CNS). However, the underlying molecular mechanism of the neuroprotective effect of MT remains unclear,
[Matrine alleviates N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric mucosal damage in rats and its mechanism].
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Objective To investigate the effect of matrine on gastric mucosal injury induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in rats and its mechanism. Methods A total of 75 Wister rats were randomly divided into a control group, a model group and three matrine-treated groups (100, 150 and 200
Matrine improves diabetic cardiomyopathy through TGF-β-induced protein kinase RNA-like endoplasmic reticulum kinase signaling pathway.
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Effect of matrine on transforming growth factor β1 and hepatocyte growth factor in rat liver fibrosis model.
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OBJECTIVE
To observe the preventive and control effect of matrine on transforming growth factor (TGF-β1) and hepatocyte growth factor (HGF) of liver fibrosis tissue in rats.
METHODS
A total of 48 SD rats were randomly divided into A, B, C, D groups with 12 in each, group A as the normal control
Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer.
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OBJECTIVE
To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical cancer.
METHODS
A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and then divided into groups I, II, III, IV, with 20 rats in each. For Group I, the
Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats.
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OBJECTIVE
This study was designed to investigate the cardioprotective effects of matrine on regulation of endothelial nitric oxide synthase (eNOS) and asymmetric dimethylarginine (ADMA) in isoproterenol-induced acute myocardial ischaemic rats.
METHODS
Male Sprague-Dawley rats were pretreated with
Clinical effectiveness of matrine sitz bath in treating perianal infection after chemotherapy for acute leukemia
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Background: Perianal infection is a common complication in patients with acute leukemia receiving chemotherapy. It usually manifests as a perianal mass, with redness/swelling, heat, and pain, and can affect physical and mental health in severe cases. The purpose of
Effect of matrine on Kupffer cell activation in cold ischemia reperfusion injury of rat liver.
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OBJECTIVE
To study the effect of matrine on activation of Kupffer cell during cold ischemia and reperfusion injury in rat orthotopic liver transplantation (OLT).
METHODS
168 syngeneic SD rats were randomly divided into four groups: untreated group, small-dose treated group, large-dose treated group
Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice.
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Acute lung injury (ALI) is a major cause of morbidity and mortality globally, and is characterized by widespread inflammation in the lungs. Increased production of reactive oxygen species is hypothesized to be associated with ALI. Matrine and lycopene are active products present in traditional
[Inhibition of tumor growth in tumor-bearing mice treated with matrine].
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OBJECTIVE
To investigate the inhibitory effect of matrine on tumor growth in tumor-bearing mice and explore its possible mechanisms of anti-tumor action in vivo.
METHODS
Hepatocellular carcinoma cells H(22) were subcutaneously injected into BALB/c mice and matrine was administered to the
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