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Identification of narciclasine from Lycoris radiata (L'Her.) Herb. and its inhibitory effect on LPS-induced inflammatory responses in macrophages.

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Lycoris radiata (L'Her.) Herb. (L. radiata) was traditionally used as a folk medicine in China for treatment of Alzheimer's disease. However, the specific component responsible for its considerable toxicity remained unclear thus restricting its clinical trials. Narciclasine (NCS) was isolated from

[Study on chemical constituents of the bulbs of Lycoris longituba].

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OBJECTIVE To study the chemical constituents of the Bulbs of Lycoris longituba. METHODS The chemical constituents were isolated and purified by means of chromatographic techniques and their structures were elucidated by spectroscopic methods. RESULTS Six compounds were isolated and identified as

Molecular Cloning and Characterization of a meta/para-O-Methyltransferase from Lycoris aurea.

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O-methyltransferases (OMTs) have been demonstrated to play key roles in the biosynthesis of plant secondary metabolites, such as alkaloids, isoprenoids, and phenolic compounds. Here, we isolated and characterized an OMT gene from Lycoris aurea (namely LaOMT1), based on our previous transcriptome

Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimer's Disease.

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We found that an extract of Lycoris chejuensis and its three isolated active components, narciclasine, 7-deoxynarciclasine, and 7-deoxy-trans-dihydronarciclasine, each significantly reduced the formation of amyloid-β peptides in HeLa cells transfected with an amyloid precursor protein carrying the

Analysis of bioactive Amaryllidaceae alkaloid profiles in Lycoris species by GC-MS.

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The genus Lycoris, a group of Amaryllidaceae plants distributed in temperate regions of Eastern Asia, is already known for containing representative alkaloids typical of this botanical family with a wide range of biological activities (for example, lycorine and galanthamine). In the present work,

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