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quinoline/inflammation
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Analgesic and anti-inflammatory 4-OH quinoline carboxylic acid derivatives
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STATE OF THE ART
U.S. Pat. No. 4,486,438 describes 4-hydroxy-3-quinoline carboxylic acid derivatives and in particular racemic 4-hydroxy2-1-hydroxypropyl) N-(2-thiazolyl)-8-trifluoromethyl-3-quinolinecarboxamide as having analgesic activity.
OBJECTS OF THE INVENTION
It is an object of the invention
Anti-inflammatory 2-substituted-4-hydroxy-3-quinoline carboxamides
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STATE OF THE ART
Related 3-quinoline carboxylic acid derivatives are described in commonly assigned U.S. Pat. Nos. 4,299,831, 4,397,856, 4,107,310 and 4,486,438.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel 3-quinoline carboxylic acid derivatives of formula I and
Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
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The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors.
From the prior art of DE 100 38 639 and WO02/10143, inflammation inhibitors of the general formula ##STR2##
are known, whereby the Ar radical comprises
Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
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The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors.
From the prior art of DE 100 38 639 and WO02/10143, inflammation inhibitors of the general formula
##STR00002## are known, whereby the Ar radical comprises
Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
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The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors.
From the prior art of DE 100 38 639 and WO02/10143, inflammation inhibitors of the general formula
##STR00002## are known, whereby the Ar radical comprises
Imidazo [4,5-C]quinoline derivatives and their use in the treatment of tumors and/or inflammation
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This is a 371 application of PCT/IN2009/052819 filed on Jun. 30, 2009, the content of which is incorporated herein by reference.
FIELD OF THE INVENTION
The present invention relates to imidazo[4,5-c]quinoline derivatives, processes for their preparation, pharmaceutical compositions containing them
4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
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STATE OF THE ART
U.S. Pat. No. 4,486,438 describes racemic 4-hydroxy-2-(1-hydroxypropyl)-N-(2-thiazolyl)-8-trifluoromethyl-3-quinolin e-carboxamide as having analgesic activity.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel compounds of formula I and their salts with
6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
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The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinolines, to a process for their preparation, to their pharmaceutical compositions and to the use of such compounds and their pharmaceutical compositions for the treatment of pain and inflammatory
6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
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The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinolines, to a process for their preparation, to their pharmaceutical compositions and to the use of such compounds and their pharmaceutical compositions for the treatment of pain and inflammatory
Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents
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The present invention is directed to novel amidines of 2-heteroaryl-quinazoline and quinolines, to a process for their preparation, to their pharmaceutical compositions and to the use of such compounds and their pharmaceutical compositions for the treatment of pain and inflammatory related
2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-inflammatory compositions and methods employing them
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STATE OF THE ART
Commonly assigned U.S. Pat. Nos. 3,992,540 and 4,107,310 and J. Het. Chem., Vol. 2, No. 2 (1965), Pennsylvania described related compounds.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel 3-quinoline carboxamides of formula I' and a process for their
Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity
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STATE OF THE ART
U.S. Pat. No. 4,486,438 describes related 4-hydroxy-3-quinoline-carboxylic acid derivatives.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel compounds of formula I and their non-toxic, pharmaceutically acceptable acid addition salts and a process for
Certain 1,3-dihydro-1-[heterocyclic)imino]-furo-[3,4-b]quinoline 9-ol compounds having analgesic and anti-inflammatory activity
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STATE OF THE ART
Commonly assigned U.S. Pat. Nos. 4,299,831 and 4,107,310 and commonly assigned U.S. patent application Ser. No. 262,952 filed May 12, 1981, now U.S. Pat. No. 4,397,856 described various 3-quinoline-carboxamides of different structure.
OBJECTS OF THE INVENTION
It is an object of the
Quinoline derivatives for the treatment of inflammatory diseases
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FIELD OF THE INVENTION
The invention relates to the identification of novel quinoline derivatives which are efficient for treating and/or preventing inflammatory diseases, as well as novel therapeutic uses of quinoline derivative towards inflammatory diseases.
The invention also relates to the field
Substituted quinolines and their uses in treatment of inflammatory and related conditions
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The present invention relates generally to phosphatidylinositol 3-kinase (PI3K) enzymes, and more particularly to selective inhibitors of PI3K activity and to methods, of using such materials.
BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a
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