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6 resultat
Pyrazolo-quinoline derivatives for treating cerebral ischemia
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This invention relates to a class of 3,5-dihydro-1H-pyrazolo[3,4-c]quinoline-1,4(2H)-dione derivatives which are substituted in the 2-position by an optionally substituted phenyl moiety. These compounds are selective non-competitive antagonists of N-methyl-Disparate (NMDA) receptors. More
Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is to imidazo[1,5-a]quinolines which are useful pharmaceutical agents for the treatment of anxiety, sleep disorders, panic states, convulsions and muscle disorders.
2. Description of the Related Art
EP 283,162 discloses
2,4-substituted quinoline derivatives
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to heterocyclic derivatives, especially quinoline carbonyl pyrrolidines that bind with high selectivity and high affinity to the benzodiazepine site of GABA.sub.A receptors. This invention also relates to pharmaceutical
Substituted 4-oxo-quinoline-3-carboxamides
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to 4-oxo-quinoline-3-carboxamides and more specifically to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABA.sub.A receptors. This invention also relates to pharmaceutical
Substituted fused pyrazolecarboxylic acid arylamides and related compounds
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FIELD OF THE INVENTION
This invention relates to substituted fused pyrazolecarboxylic acid arylamides and related compounds, such as substituted fused pyrazolecarboxylic acid arylamides that bind with high selectivity and high affinity to the benzodiazepine site of GABA.sub.A receptors. This
Anticonvulsive agents and uses thereof
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BACKGROUND OF THE INVENTION
The present invention relates to a agents useful as excitatory amino acid antagonists. The quinoline and kynurenin derivatives of the present invention have affinity for the glycine binding site of the NMDA receptor. Compounds of the present invention should be usable for
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