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SENSORY NEURON DEGENERATION IN VITAMIN DEFICIENCY : DEGENERATION OF THE POSTERIOR COLUMNS OF THE SPINAL CORD, PERIPHERAL NERVES, AND DORSAL ROOT GANGLION CELLS IN YOUNG PIGS FED A DIET CONTAINING THIAMIN (B(1)) AND RIBOFLAVIN BUT OTHERWISE DEFICIENT IN VITAMIN B COMPLEX.

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Young pigs were given an artificial diet presumably adequate in all respects. As they developed, the quantity of yeast was gradually reduced while thiamin (vitamin B(1)) and riboflavin were given in its place. The rate of growth decreased, the general condition of the animals became impaired, and

Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration.

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OBJECTIVE To report the results of corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A irradiation in a patient affected by pellucid marginal degeneration (PMD). METHODS A 43-year-old man with bilateral PMD underwent CXL in the left eye. The treatment was performed in standard

Differential effects of riboflavin and RRR-alpha-tocopheryl acetate on the survival of newborn RCS rats with inheritable retinal degeneration.

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The dystrophic RCS rat is one of the most important animal models available for investigating retinal degeneration. In addition to the characteristic progressive loss of neural retina the strain is hampered by a high rate of mortality during the first week of life. Death rate during this period is

Ablation of the riboflavin-binding protein retbindin reduces flavin levels and leads to progressive and dose-dependent degeneration of rods and cones.

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The interface between the neural retina and the retinal pigment epithelium (RPE) is critical for several processes, including visual pigment regeneration and retinal attachment to the RPE. One of its most important functions is the exchange of metabolites between the photoreceptors and RPE because

Dietary riboflavin deficiency induces ariboflavinosis and esophageal epithelial atrophy in association with modification of gut microbiota in rats

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Purpose: Riboflavin deficiency causes ariboflavinosis, a common nutritional deficiency disease. The purpose of this study is to investigate the effects of riboflavin deficiency on the important internal organs and its potential mechanisms.

Riboflavin-mediated axonal degeneration of postnatal retinal ganglion cells in vitro is related to the formation of free radicals.

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It is well known that glial cells produce several neurotrophic factors. We detected a neurogedegenerative/neurite growth inhibiting activity in serum-free astrocyte-conditioned medium (ACM). After high performance liquid chromatography (HPLC)-purification, spectral analysis and test of biologic

The effect of riboflavin/UVA cross-linking on anti-degeneration and promoting angiogenic capability of decellularized liver matrix.

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Weak mechanical property and unstable degradation rate limited the application of decellularized liver matrix in tissue engineering. The aim of this study was to explore a new method for improving the mechanical properties, anti-degeneration and angiogenic capability of decellularized liver matrix.

Oxidation of rapeseed oil in waste activated bleaching earth and its effect on riboflavin production in culture of Ashbya gossypii.

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Long-term behavior of rapeseed oil in waste activated bleaching earth (ABE) and the effect of this oil on riboflavin production in the culture of Ashbya gossypii were investigated. Waste ABE with 40% (w/w) rapeseed oil was stored for 80 d, and the extent of oxidation of rapeseed oil was measured by

Effect of room fluorescent light on the deterioration of tissue culture medium.

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A major cause of tissue culture medium deterioration is exposure to room fluorescent light. Riboflavin and tryptophan present in Dulbecco's modified Eagle's minimum essential medium, when exposed to light, yield toxic photoproducts responsible for loss of the ability of the medium to support clonal

[Effect of riboflavin (vitamin B2) on spontaneous gonarthrosis in the mouse].

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Male mice of the C57 black strain were given 1 mg/kg body weight of riboflavin (vitamin B2) in their drinking water daily for 4 months, in addition to the vitamin B2 contained in their standard pellet feed. Controls received the standard feed only. Histological examination of the joints at the end

Flavin homeostasis in the mouse retina during aging and degeneration.

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Involvement of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) in cellular homeostasis has been well established for tissues other than the retina. Here, we present an optimized method to effectively extract and quantify FAD and FMN from a single neural retina and its corresponding

Peripheral neuropathy of dietary riboflavin deficiency in chickens.

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A strain of rapidly growing meat-type chickens was fed a diet deficient in riboflavin from 1-40 days of age. Diminished growth rate, progressive gait abnormality and reluctance to move were noted beginning on day 8. Neurologic abnormalities were related to peripheral neuropathy characterized by

Riboflavin status in Gambian pregnant and lactating women and its implications for Recommended Dietary Allowances.

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Riboflavin status by the erythrocyte glutathione reductase (NAD(P)H2:glutathione oxidoreductase EC1.6.4.2) test, and dietary riboflavin intake, were measured in 156 pregnant and lactating women in Keneba, a rural Gambian village, and in 59 pregnant and lactating women in Cambridge, England. The

Riboflavin status in acutely ill patients and response to dietary supplements.

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BACKGROUND Although a number of studies have reported riboflavin deficiency in free-living older people, no data are available on riboflavin intake and status in older people during acute illness. METHODS To determine the riboflavin response to dietary supplements during acute illness, 297

Reusable light-emitting-diode induced chemiluminescence aptasensor for highly sensitive and selective detection of riboflavin.

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A novel reusable chemiluminescence aptasensor was developed based on aptamer recognition coupled with light-emitting-diode induced chemiluminescence (LED-CL) detection. The sensing approach was based on the design that the model analyte riboflavin (Rf) in sample solutions was captured by the

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