The participants received modern routing standard therapy accompanied with the round plastic studs of sea-band were placed just on the skin surface of bilateral PC6 acupoints , and then keep the persistent compressive state for 3 minutes per time and three times a day.

The participants received modern routing standard therapy only with general elastic band without bud over PC6 acupoints.

Migraine; Status

The PC6 acupressure was done via Sea-Band in persistent compressive state for 3 minutes per time and three times a day , then at least 5 days in one week for 6 weeks continuously except modern routine standard therapy

Acupressure elastic band (Sea-Band)

general elastic band was put over bilateral PC6 acupoints

General elastic band (no bud)

National Taiwan University Hospital Yunlin Branch

Effect of Acupressure in Migraine: Single-blinded, Randomized, Controlled Clinical Trial

Effect of Acupressure at PC6 on Headache in Patients With Migraine: Single-blinded, Randomized, Controlled Clinical Trial

duration (if attack less than 4hours which means better response)

Severity by visual analog scale (0~10), if VAS score decreased 2 points which means better results

how many times headache occurred (if attack < 8 times which means effective)

how many dosage of pain kill taken (if pain killer taken less than 20 pills which means effective therapy)

Check serum CGRP level to evaluate the correlation

Check NKA level to realize any discrepancy

Complete form for quality evaluation (score: 0~100, worse to better)

National Taiwan University Hospital

China Medical University, Taiwan

Patients with a clinical presentation suggestive of mitochondrial cytopathy, in whom mitochondrial deletions above 20% have been found in muscle are considered eligible if they are older than 18 years and are willing and able to give written informed consent.

Twenty healthy individuals matched for age and gender will be included in the study and considered as controls.

Whole blood, urine. All samples collected in this study (blood and urinary) will be sent to a central biobank for long term storage.

Mitochondrial Diseases

Mitochondrial Myopathies

Mitochondrial Cytopathies

Department of Endocrinology, Diabetes and Clinical Nutrition, Bern University Hospital

Nutritional Assessment in Mitochondrial Cytopathy

Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy

Measured in kcal (7 days food recall protocol to check for nutrients which aggravate symptoms & to provide nutritional counselling)

Measured in laboratory parameters (blood and urine)

valproic acid/kräkning

Effect of Acupressure in Migraine: Single-blinded, Randomized, Controlled Clinical Trial

Nutritional Assessment in Mitochondrial Cytopathy

Efficacy Study of Galantamine for Cognitive Impairments in Schizophrenia

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