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visceral pain/stroke
Länken sparas på Urklipp
5 resultat
L-N.sup.5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
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TECHNICAL FIELD
The invention is directed at certain ornithine and lysine derivatives which are selective, mechanism-based inactivators of neuronal isoform of nitric oxide synthase and selective inhibitors of nitric oxide synthase.
BACKGROUND OF THE INVENTION
Nitric oxide synthase (NOS) catalyzes
N-substituted oxindoline derivatives as calcium channel blockers
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FIELD OF THE INVENTION
This invention relates to a series of N-substituted oxindoline derivatives. In particular, this invention relates to N-substituted oxindoline derivatives that are N-type voltage-gated calcium channel blockers useful for the treatment of a variety of pain conditions including
Substituted aryl sulfone derivatives as calcium channel blockers
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FIELD OF THE INVENTION
This invention relates to a series of substituted aryl sulfone derivatives. In particular, this invention relates to substituted aryl sulfone derivatives that are N-type voltage-gated calcium channel blockers useful for the treatment of a variety of pain conditions including
Benzimidazolone derivatives as CB2 receptor ligands
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BACKGROUND OF THE INVENTION
This invention relates to benzimidazolone derivatives. These compounds have selective cannabinoid(CB)2 receptor binding activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the
Sulfonyl benzimidazole derivatives
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BACKGROUND OF THE INVENTION
This invention relates to sulfonyl benzimidazole derivatives. These compounds have selective cannabinoid (CB)2 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives
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