Not-celiac Wheat Sensitivity (NCWS)

Familial Mediterranean Fever (FMF)

Wheat flour will be administered once daily for 7 days

Wheat flour

Placebo Comparator

Department of Internal Medicine, Giovanni Paolo II Hospital of Sciacca

Department of Internal Medicine, University Hospital of Palermo

Gluten-related Disorders in Familial Mediterranean Fever Patients

Gluten-related Disorders in Patients Affected With Familial Mediterranean Fever

Fibromyalgia symptoms of patients, evaluated by the International Severity Scoring System for Familial Mediterranean Fever (ISSF), will be scored before and after 1 week of wheat (or placebo) ingestion

Gastrointestinal symptoms of patients, evaluated by the Gastrointestinal Symptom Rating Scale (GSRS), will be scored before and after 1 week of wheat (or placebo) ingestion

There will be evaluated some leukocytes cell surface antigens expression, i.e. CD45, CD56, CD117, NKp44, CD3, CD19, and CD14, from peripheral blood mononuclear cells and rectal mucosal lymphocytes before and after 1 week of wheat (or placebo) ingestion

There will be evaluated some cytokines production, i.e. IFN-γ, TNF-α, IL-22, IL-17, and T-bet, from peripheral blood mononuclear cells and rectal mucosal lymphocytes before and after 1 week of wheat (or placebo) ingestion

wheat hypersensitivity/feber

Gluten-related Disorders in Familial Mediterranean Fever Patients

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