Brown Fat Activity and White Fat Accumulation

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliImekamilika

Wadhamini

Children's Hospital Los Angeles

JARIBIO LA KLINIKI: NCT01517581

BioSeek: NCT01517581

Maneno muhimu

Kikemikali

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Tarehe

Imethibitishwa Mwisho:	12/31/2011
Iliyowasilishwa Kwanza:	01/19/2012
Uandikishaji uliokadiriwa Uliwasilishwa:	01/23/2012
Iliyotumwa Kwanza:	01/24/2012
Sasisho la Mwisho Liliwasilishwa:	01/23/2012
Sasisho la Mwisho Lilichapishwa:	01/24/2012
Tarehe halisi ya kuanza kwa masomo:	09/30/2008
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	08/31/2011
Tarehe ya Kukamilisha Utafiti:	08/31/2011

Hali au ugonjwa

Hodgkins Lymphoma

Non-hodgkins Lymphoma

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Malignant Disease with no visualized BAT Children 18 years or younger who 1) had PET/CT scans with evidence of malignant disease but no metabolically active brown adipose tissue (BAT) at diagnosis and 2) were disease free within 1 year of diagnosis.

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	6 Years Kwa 6 Years
Jinsia Inastahiki Kujifunza	All
Njia ya sampuli	Non-Probability Sample
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - Patients had PET/CT scans with evidence of malignant disease - Patients had no metabolically active BAT at diagnosis on their PET/CT scan - Patients were disease free within 1 year of diagnosis Exclusion Criteria: - Patients had PET/CT scans with no evidence of malignant disease - Patients with metabolically active BAT at diagnosis on their PET/CT scan - Patients were not disease free within 1 year of diagnosis

Matokeo

Hatua za Matokeo ya Msingi

1. Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up [Baseline and up to 1 year]

2. Change from Baseline in Visceral Adipose Tissue Volume at Follow-up [Baseline and up to 1 year]

3. Change from Baseline in Presence of Brown Adipose Tissue [Baseline and up to 1 year]

4. Change from Baseline in Abdominal Musculature Volume [Baseline and up to 1 year]

Hatua za Matokeo ya Sekondari

1. Change from Baseline in Anthropometric Measures at Follow-up [Baseline and up to 1 year]

Age, height, weight and BMI