Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis
Maneno muhimu
Kikemikali
Maelezo
Takayasu's arteritis and Giant Cell arteritis are chronic, relapsing diseases of the large arteries which can lead to significant narrowing of the arteries through episodes of inflammation within the artery walls. The changes in the vessel walls will be determined by an ultrasound test looking at and measuring: carotid vessel wall changes called carotid Intimal-Media Thickness (cIMT) and the presence of new blood vessels (neovascularization) using a contrast agent. Ultrasound findings will be correlated with markers of inflammation in the blood, findings from other radiology studies (such as MRI) already ordered as part of routine clinical care, and physical exam findings and symptoms of consistent with disease activity. 15 arteritis patients and 5 healthy controls will be recruited.
Tarehe
| Imethibitishwa Mwisho: | 12/31/2016 |
| Iliyowasilishwa Kwanza: | 02/17/2013 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 02/17/2013 |
| Iliyotumwa Kwanza: | 02/19/2013 |
| Sasisho la Mwisho Liliwasilishwa: | 01/25/2017 |
| Sasisho la Mwisho Lilichapishwa: | 01/26/2017 |
| Tarehe halisi ya kuanza kwa masomo: | 07/31/2010 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 12/31/2013 |
| Tarehe ya Kukamilisha Utafiti: | 12/31/2013 |
Hali au ugonjwa
Awamu
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Njia ya sampuli | Non-Probability Sample |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Male and female patients >18 years - Diagnosis of Takayasu's arteritis or giant cell arteritis - Suspicion of common carotid involvement on the basis of physical examination (cervical bruit), carotidynia, documented CCA involvement on an imaging study (MRA, CTA, or ultrasound), or documented upper extremity large vessel involvement on an imaging study (MRA or CTA or ultrasound). - Ability to provide informed consent Exclusion Criteria: - Prior stroke, carotid surgery or angioplasty - Pregnant (or trying to become pregnant) - Nursing - Known or suspected cardiac shunt - Documented hypersensitivity to the contrast agent - Severe pulmonary hypertension or unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, serious ventricular arrhythmias, or respiratory failure) |
Matokeo
Hatua za Matokeo ya Msingi
1. Correlation between carotid IMT and neovascularization and disease activity [3 days]
