Hypoxia and Exercise in the Elderly

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliImekamilika

Wadhamini

Hannover Medical School

Washirika

German Diabetes Center

JARIBIO LA KLINIKI: NCT02196623

BioSeek: NCT02196623

Maneno muhimu

Kikemikali

Ageing is the primary risk factor for most chronic diseases including type 2 diabetes mellitus. Sarcopenia and muscular mitochondrial dysfunction with aging are crucial mechanisms leading to decreased exercise tolerance and worsened insulin sensitivity. Thus, metabolic disease and frailty, which limits physical mobility as well as quality of life, share common cellular mechanisms.

The investigators will test the hypothesis that a combination of normobaric hypoxia and exercise training elicits a synergistic effect on age-associated metabolic skeletal muscle dysfunction and the investigators will address the molecular mechanisms. In a randomized clinical study, the investigators will compare normoxic and hypoxic training conditions in elderly subjects. Outcome measures will focus on whole body insulin sensitivity and mitochondrial responses in skeletal muscle before and after the 8-week training intervention.

Tarehe

Imethibitishwa Mwisho:	07/31/2017
Iliyowasilishwa Kwanza:	07/17/2014
Uandikishaji uliokadiriwa Uliwasilishwa:	07/17/2014
Iliyotumwa Kwanza:	07/21/2014
Sasisho la Mwisho Liliwasilishwa:	01/22/2019
Sasisho la Mwisho Lilichapishwa:	01/23/2019
Tarehe halisi ya kuanza kwa masomo:	05/31/2015
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	08/31/2017
Tarehe ya Kukamilisha Utafiti:	12/31/2018

Hali au ugonjwa

Elderly Persons

Uingiliaji / matibabu

Other: Hypoxic Exercise

Other: Normoxic exercise

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Experimental: Hypoxic Exercise Supervised, progressive aerobic exercise for 8 weeks under hypoxic conditions	Other: Hypoxic Exercise Supervised, progressive aerobic exercise program for 8 weeks under hypoxic conditions
Sham Comparator: Normoxic exercise Supervised, progressive aerobic exercise for 8 weeks under normoxic conditions	Other: Normoxic exercise Supervised, progressive aerobic exercise program for 8 weeks under normoxic conditions

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	55 Years Kwa 55 Years
Jinsia Inastahiki Kujifunza	All
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - 55 to 75 years of age - body mass index: 20 - 35 kg/m2 - weight stable during last 6 months before screening (weight change < 2% body weight) - HOMA-index of insulin resistance ≥ 2 to 4 units Exclusion Criteria: - more than 1 hour of scheduled exercise training per week - known diagnosis of type 2 diabetes or measured HbA1c > 6,5% - known drug or alcohol abuse - any contraindication to perform exercise training - acute or chronic infections - increased bleeding risk by history, INR > 1,3, use of anticoagulants

Matokeo

Hatua za Matokeo ya Msingi

1. Insulin sensitivity [At baseline and after 8 weeks]

Insulin sensitivity is assessed via the hyperinsulinemic euglycemic glucose clamp and expressed as the glucose infusion rate (GIR) in ml

Hatua za Matokeo ya Sekondari

1. Maximum oxygen uptake [At baseline and after 8 weeks]

Maximum oxygen uptake is measured during an incremental exhaustive exercise test and is expressed in ml/min/kg

2. Mitochondrial number [At baseline and after 8 weeks]

Mitochondrial number and selected gene expression assessed from muscle biopsies from the vastus lateralis.

3. Fat and carbohydrate oxidation during exercise [At baseline and after 8 weeks]

Fat and carbohydrate oxidation during exercise is assessed during an incremental exercise test by measurements of gas exchange and expressed as g/min

4. Body fat and body fat free mass [At baseline and after 8 weeks]

Measured via by air-displacement plethysmography (ADP) and expressed in kg

5. Health related quality of life [At baseline and after 8 weeks]

Assessed using the short form 36 (SF-36) questionnaires

Hypoxia and Exercise in the Elderly

Maneno muhimu

hypoxia

sarcopenia

kisukari aina ya 2

kisukari

insulin resistance