Long Term Prognosis of Taiwanese Patients With OSA
Maneno muhimu
Kikemikali
Maelezo
Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation. OSA is associated with cardiovascular morbidity and mortality, metabolic dysregulation, and neurocognitive dysfunction, which may bring worse prognosis. Continuous positive airway pressure (CPAP) is the standard treatment of OSA while the oral appliance and surgery are the alternative treatments. The differences of craniofacial features among races contributed to the race-specific presentations of OSA. Up to date, only limited studies investigated the long-term prognosis of OSA and most of them recruited Caucasians and African Americans. Moreover, most studies didn't address the impact of treatment other than CPAP on the long-term prognosis. .
National Health Insurance Research Database (NHIRD) in Taiwan enrolled 99% of whole Taiwan's population and has longer period of 10 years for follow-up, which is suitable for investigation of long-term prognosis and predictors in OSA. However, due to limited parameters for diagnosis and treatment, the results could be biased in such secondary database research. Center of Sleep Disorder in National Taiwan University Hospital (NTUH) established from 2006 has 2,600 sleep studies annually. Therefore, database and cohort from sleep center could offer the validations of the prognosis and predictors determined from NHIRD. In addition, the impact of all three treatment modalities, namely CPAP, oral appliance, and surgery, on long-term prognosis could be studied in the prospective way.
Therefore, in this project, we aimed to achieve three goals (1) To explore long-term prognosis and identify the predictors in Taiwanese OSA patients with NHIRD, where the prediction mode of prognosis was established (2). To validate the prediction model derived from NHIRD with the database of NTUH sleep center (3) To determine the effects of different treatments on long-term prognosis with prospective following NTUH sleep center cohort.
Tarehe
| Imethibitishwa Mwisho: | 02/28/2014 |
| Iliyowasilishwa Kwanza: | 03/15/2014 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 03/15/2014 |
| Iliyotumwa Kwanza: | 03/17/2014 |
| Sasisho la Mwisho Liliwasilishwa: | 03/15/2014 |
| Sasisho la Mwisho Lilichapishwa: | 03/17/2014 |
| Tarehe halisi ya kuanza kwa masomo: | 12/31/2013 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 11/30/2017 |
| Tarehe ya Kukamilisha Utafiti: | 11/30/2017 |
Hali au ugonjwa
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| NHIRD obstructive sleep apnea Secondary database from community-based National Health Insurance Research Database | |
| NTUH obstructive sleep apnea cohort Primary database from enrollment of retrospective NTUH hospital-based cohort |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 20 Years Kwa 20 Years |
| Jinsia Inastahiki Kujifunza | All |
| Njia ya sampuli | Probability Sample |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - NHIRD - >=20 y/o; OSA ICD-9-CM code: 780.51,780.53,780.57, or 327.23; coexisted with PSG procedure code: 17008B,17008A. - NTUH cohort - >=20 y/o; PSG AHI>5 Exclusion Criteria: - patients refusing to anticipate our study |
Matokeo
Hatua za Matokeo ya Msingi
1. Death or Major adverse cardiovascular events(MACEs) [from 2000 to 2013, up to 13 years]
Hatua za Matokeo ya Sekondari
1. Cardiovascular morbidity [from 2000 to 2013, up to 13 years]
2. Neurocognitive morbidity, up to 13 years [from 2000 to 2013, up to 13 years]
3. Metabolic morbidity [from 2000 to 2013, up to 13 years]
4. Other morbidity [from 2000 to 2013, up to 13 years]
