Regional Distribution of Ventilation in Patients With Chronic Heart Failure
Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Kiungo kimehifadhiwa kwenye clipboard
HaliImekamilika
Wadhamini
Universidade Federal de Pernambuco
JARIBIO LA KLINIKI: NCT01292902
BioSeek: NCT01292902
Maneno muhimu
Kikemikali
Inspiratory muscle dysfunction is a reduction in the ability to generate pressure and force by the inspiratory muscles. This decrease in the strength of these muscles can be attributed to biochemical and histological changes. Some patients with CHF showed a reduction of maximal inspiratory pressure (MIP) and inspiratory muscle endurance, and such factors known to exercise limitation and deterioration in quality of life and worsens the prognosis of these patients. This study aims to evaluate the Regional pulmonary distribution volume and the influence of enclosures system thoracoabdominal in CHF patients with cardiomegaly associated with diaphragmatic weakness during quiet breathing and during exercise for inspiratory muscle and its correlation with functional data. The investigators evaluated a total of 31 individuals divided into two groups: CHF and control. In the control group, twelve volunteers participated with similar age, gender and body mass index in relation to the group of patients with CHF. The control group participants had an ejection fraction of left ventricle (EF)> 50% without cardiac abnormalities of the cameras and MIP over 80% of predicted. To conduct the exercise to the inspiratory muscles (EMI) was used for IMT Threshold ® device (Threshold Inspiratory Muscle Trainer, HealthScan Products Inc., Cedar Grove, New Jersey) is one of the most used for training of inspiratory muscles in patients with several pathologies such as CHF. The exercise time was 3 minutes. During this period, participants were encouraged to only breathe through the mouth and maintain a respiratory rate between 12 and 16ipm. Opto-electronic plethysmography measures the volume changes of thoracoabdominal system by placing 89 markers formed by hemiesferas covered with retro-reflective paper, taking the place of each of these hemiesferas determined by anatomical landmarks on the anterior and posterior regions of the chest and abdomen. According to our study, a lower ventilation on diaphragmatic region would lead to an increased perception of dyspnea during submaximal exercise in this population. Moreover, the observed changes in the pattern of regional distribution of ventilation in CHF patients compared to healthy individuals can serve as a basis for prospective cohort studies using IMT.
Tarehe
| Imethibitishwa Mwisho: | 12/31/2010 |
| Iliyowasilishwa Kwanza: | 02/08/2011 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 02/08/2011 |
| Iliyotumwa Kwanza: | 02/09/2011 |
| Sasisho la Mwisho Liliwasilishwa: | 02/08/2011 |
| Sasisho la Mwisho Lilichapishwa: | 02/09/2011 |
| Tarehe halisi ya kuanza kwa masomo: | 06/30/2010 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 11/30/2010 |
| Tarehe ya Kukamilisha Utafiti: | 11/30/2010 |
Hali au ugonjwa
Chronic Heart Failure
Uingiliaji / matibabu
Other: chronic heart failure
Other: healthy volunteers
Awamu
-
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Active Comparator: healthy volunteers | Other: healthy volunteers Equal to the group with chronic heart failure. |
| Other: chronic heart failure | Other: chronic heart failure To conduct the exercise to the inspiratory muscles was used for IMT Threshold ® device (Threshold Inspiratory Muscle Trainer, HealthScan Products Inc., Cedar Grove, New Jersey) is one of the most used for training of inspiratory muscles in patients with several pathologies such as ICC.Threshold ® has been engaged in the patient's mouth by a mouthpiece, with the nose occluded by a nose clip. The exercise time was 3 minutes. During this period, participants were encouraged to only breathe through the mouth and maintain a respiratory rate between 12 and 16ipm. The exercise would be stopped if HR increased more than 20% and / or SpO2 < 88%. |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 21 Years Kwa 21 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Diagnosed as CHF associated with cardiomegaly - Class II and III (NYHA) - Left ventricular minor 45% (method Teicholtz) - Inspiratory muscle weakness (PiMáxima <70% predicted) - Duration of symptoms > 1 year - Body mass index (BMI) < 35kg/m2 - Non-smokers or former smokers with a smoking history < 10 pack-years Exclusion Criteria: - Patients with chronic heart failure who had unstable angina, myocardial infarction or heart surgery until three months before the survey - Orthopedic diseases or respiratory comorbidities such as asthma and COPD |
Matokeo
Hatua za Matokeo ya Msingi
1. Opto-electronic plethysmography [1 year]
The POE (BTS Bioengineering, Italy) measures the volume changes of thoracoabdominal system through placement of 89 markers formed by hemiesferas covered with retro-reflective paper, taking the place of each of these hemiesferas determined by anatomical landmarks in anterior and posterior thorax and abdomen.
Hatua za Matokeo ya Sekondari
1. Assessment of Functional Capacity [1 year]
To assess the functional capacity test was used for 6-minute walk (6MWT) according to the protocol established by the American Thoracic Society (ATS). Before the test parameters were assessed resting blood pressure (BP), Heart Rate (HR), Oxygen Saturation (SpO2 - pulse oximetry portable Onix 9500), Respiratory Frequency (RF) and dyspnea scale (scale Borg).
