Study of Circulating Microparticles in Giant Cell Arteritis

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

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Hali

Wadhamini

University Hospital, Caen

JARIBIO LA KLINIKI: NCT02333708

BioSeek: NCT02333708

Maneno muhimu

Kikemikali

To demonstrate that microparticles (MPs), having a powerful procoagulant potential, are in larger amounts in the blood of patients with histologically proven giant cell arteritis (GCA), compared with patients matched for age, sex and with or without inflammatory syndrome.

Tarehe

Imethibitishwa Mwisho:	08/31/2016
Iliyowasilishwa Kwanza:	01/04/2015
Uandikishaji uliokadiriwa Uliwasilishwa:	01/05/2015
Iliyotumwa Kwanza:	01/06/2015
Sasisho la Mwisho Liliwasilishwa:	07/15/2018
Sasisho la Mwisho Lilichapishwa:	07/16/2018
Tarehe halisi ya kuanza kwa masomo:	08/31/2015
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	09/15/2018
Tarehe ya Kukamilisha Utafiti:	10/31/2018

Hali au ugonjwa

Giant Cell Arteritis

Acute Phase

Uingiliaji / matibabu

Other: Blood sample

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
GCA group
Inflammatory syndrome (without GCA) group
Without inflammatory syndrome and without GCA group

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Years Kwa 18 Years
Jinsia Inastahiki Kujifunza	All
Njia ya sampuli	Non-Probability Sample
Hupokea Wajitolea wa Afya	Ndio
Vigezo	For GCA group: Inclusion Criteria: - Men and women ≥ 18 years of age Patient affiliated to social security regimen - Informed and having signed the consent form to take part in the study. - Diagnosis of GCA, meeting at least 3 of the following 5 American College of Rheumatology (ACR) criteria for the diagnosis of GCA, including inflammatory syndrome and having - Either temporal artery biopsy showing characteristic GCA abnormality - Or inflammatory arteritis on imaging examination Exclusion Criteria: - Persons under protection of the court or guardianship - Inability to understand or to follow study procedures - Dementia - cancer diagnosed within the previous 5 years (except for non-melanoma skin cancer or in situ carcinoma of the cervix)non-contributory or inconclusive temporal artery biopsy - Any conditions that might interfere with MPs level: diabetes, recent endo-arterial gesture, current treatment with corticosteroids. - Participation in another ongoing clinical trial Current anticoagulant therapy - Active infectious disease

Matokeo

Hatua za Matokeo ya Msingi

1. Level of microparticles in the blood of patients with histologically proven giant cell arteritis. [Baseline]

Level of microparticles (MPs) in the blood of patients with histologically proven giant cell arteritis (GCA), compared with patients matched for age, sex and with or without inflammatory syndrome.