Thulium Contact Laser of Laryngotracheal Stenosis
Maneno muhimu
Kikemikali
Maelezo
Laryngotracheal stenosis is a serious disease significantly worsening the quality of life. Impaired breathing often leads to tracheotomy, deterioration of the voice leads to communication problems with others and swallowing problems are often present, as well The main causes of laryngotracheal stenosis are post intubation and post tracheostomy conditions, inflammatory process (often autoimmune), tumors (mainly squamous cell carcinoma and chondroma) and trauma. Within the last years there is substantial shift in the treatment strategy from open surgery to endoscopic techniques. However, surgical treatment is often difficult due to demanding exposure of tumor and problematic margins control.
In recent years there has been a development of particular techniques of endoscopic resection of tumors and non-malignant laryngeal glottic and subglottic stenosis using a carbon dioxide (CO2) laser with promising improvement of treatment results.
However, CO2 laser has some limitations, particularly in the treatment of tumors spreading into anterior commissure, because CO2 laser beam cannot get "around the corner". Moreover, subglottic area is also difficult to be reached by CO2 laser beam. Therefore, contact laser with adjustable manipulators with possibility to bend tip of manipulator according to the actual need seems to be of some advantage.
Tarehe
Imethibitishwa Mwisho: | 06/30/2019 |
Iliyowasilishwa Kwanza: | 10/22/2015 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 10/24/2015 |
Iliyotumwa Kwanza: | 10/26/2015 |
Sasisho la Mwisho Liliwasilishwa: | 07/30/2019 |
Sasisho la Mwisho Lilichapishwa: | 07/31/2019 |
Tarehe halisi ya kuanza kwa masomo: | 09/30/2015 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 06/30/2018 |
Tarehe ya Kukamilisha Utafiti: | 08/31/2018 |
Hali au ugonjwa
Uingiliaji / matibabu
Procedure: laryngeal carcinoma
Procedure: bilateral vocal cord paralysis
Procedure: subglottic stenosis
Awamu
Vikundi vya Arm
Mkono | Uingiliaji / matibabu |
---|---|
Experimental: laryngeal carcinoma patients with T1-T2 (some T3) laryngeal carcinoma will undergo treatment using thulium contact laser surgery - tumour resection | Procedure: laryngeal carcinoma treatment of laryngeal carcinoma using thulium contact laser |
Experimental: bilateral vocal cord paralysis patients with bilateral vocal cord paralysis treated with partial arytenoidectomy will be treated using thulium laser surgery and laterofixation | Procedure: bilateral vocal cord paralysis treatment of bilateral vocal cord paralysis using thulium contact laser |
Experimental: subglottic stenosis patients with subglottic stenosis treated endoscopically (incisions and dilatation) will be treated with thulium laser surgery | Procedure: subglottic stenosis treatment of subglottic stenosis using thulium contact laser |
Vigezo vya Kustahiki
Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
Jinsia Inastahiki Kujifunza | All |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: 1. patients with T1-T2 (some T3) laryngeal carcinoma 2. patients with bilateral vocal cord paralysis treated with partial arytenoidectomy and laterofixation 3. patients with subglottic stenosis treated endoscopically Exclusion Criteria: - non signing of informed consent |
Matokeo
Hatua za Matokeo ya Msingi
1. Percentage of carcinoma recurrence in the patient population [36 months]
Hatua za Matokeo ya Sekondari
1. Percentage of decannulation in the patient population [36 months]
2. Voice quality (Voice Handicap Index) [36 months]
3. Swallowing (SWAL-QOL) questionnaire [36 months]