Apomorphine Effects on Experimental Pain
Maneno muhimu
Kikemikali
Maelezo
Healthy volunteers (n=105) participated in this randomized double-blind, placebo-controlled, cross-over trial. Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) were evaluated before and for up to 120 min after the administration of 1.5 mg apomorphine/placebo. A polymorphism (DAT-1) within the dopamine transporter gene (SLC6A3) was investigated.
Tarehe
| Imethibitishwa Mwisho: | 08/31/2016 |
| Iliyowasilishwa Kwanza: | 12/05/2012 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 12/05/2012 |
| Iliyotumwa Kwanza: | 12/06/2012 |
| Sasisho la Mwisho Liliwasilishwa: | 09/14/2016 |
| Sasisho la Mwisho Lilichapishwa: | 09/15/2016 |
| Tarehe halisi ya kuanza kwa masomo: | 06/30/2009 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 06/30/2011 |
| Tarehe ya Kukamilisha Utafiti: | 06/30/2011 |
Hali au ugonjwa
Uingiliaji / matibabu
Drug: Apomorphine
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Placebo Comparator: Saline Assessment of experimental pain models before and after treatment | |
| Active Comparator: Apomorphine Assessment of experimental pain models before and after treatment |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - healthy and free from chronic pain of any type did not use any medications other than oral contraceptives were able to understand the purpose and instructions of the study. Exclusion Criteria: - any type of medical or painful condition use of medications or recreational drugs pregnancy. |
Matokeo
Hatua za Matokeo ya Msingi
1. Cold pain tolerance [120 minutes]
