Autologous Fat Grafting to the Breast

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

Hali

Wadhamini

Louisiana State University Health Sciences Center in New Orleans

JARIBIO LA KLINIKI: NCT00775788

BioSeek: nct00775788

Maneno muhimu

Kikemikali

Structural fat grafting is a form of tissue transfer where the autologous fat is harvested and subsequently transferred to a different region of the body at the same setting. It is an excellent technique for filling soft tissue and contour defects. Fat has the benefit of being abundantly available and easy to harvest. Further more, it is cheap and autogenous and thus lacks the side effects of synthetic fillers or implants. Autogenous fat transfer is a relatively common procedure performed by plastic and reconstructive surgeons. The goal of fat grafting is to provide the patient with a predictable, long lasting autogenous soft tissue augmentation. Autogenous fat transfer has been used extensively as an adjunct to facial rejuvenation. As well it has been applied to body contouring and augmentation of the hips, trochanteric areas, thighs and buttocks, back, torso and breast. The transfer of autologous fat dates back to 1890s and more specifically as injectable grafts since the 1920s. However, over the past 20 years the popularity of structural fat grafting has increased as a contouring modality. Fat transfer to the breast, popularized by Coleman, has been performed internationally since the 1990s. Despite the duration, the literature lacks accurate outcomes data on fat transfer to the breast and questions regarding the viability of adipocytes after the transfer exist. Sources from various publications show cell viability of up to 100% however studies of long term clinical outcomes quote rates of 10% to 80%.

Maelezo

Our goal with this study is to prospectively acquire information with our protocol that will outline the accurate long-term outcomes of fat transfer to the breast. Currently, fat grafting to the breast is a treatment option in conditions such as micromastia, breast ptosis, post mastectomy breast reconstruction, asymmetric breasts, congenital malformations of breast development and for treatment of complications associated with implant augmentation mammoplasty. In addition to fat grafting, the current surgical treatment for these conditions is mainly based on techniques requiring implant augmentation or reconstruction. Although the safety of saline implants has been well studied and documented, this data cannot be extrapolated for the newer generation silicone implants and other alternatives such as fat grafting need to be investigated. Also implant augmentation and reconstruction comes at the price of capsular contracture, implant deflation, infection and more future corrective surgeries. We plan to prospectively study the outcomes of fat grafting in patients with these conditions for a period of 5 years. The collected information will be entered into a database and will be prospectively collected and reviewed. Patients demographics, information obtained during the preoperative and postoperative visits along with the pertinent findings regarding the fat transfer to the breast will be collected into the database for our investigation.

Tarehe

Imethibitishwa Mwisho:	09/30/2008
Iliyowasilishwa Kwanza:	10/14/2008
Uandikishaji uliokadiriwa Uliwasilishwa:	10/16/2008
Iliyotumwa Kwanza:	10/19/2008
Sasisho la Mwisho Liliwasilishwa:	11/16/2008
Sasisho la Mwisho Lilichapishwa:	11/17/2008
Tarehe halisi ya kuanza kwa masomo:	05/31/2008
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	05/31/2010
Tarehe ya Kukamilisha Utafiti:	05/31/2010

Hali au ugonjwa

Micromastia

Breast Ptosis

Implant Failure

Breast Reconstruction

Congenital Malformations

Uingiliaji / matibabu

Procedure: Autologous Fat Grafting to Breasts

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Experimental: Implant Failure
Experimental: Post mastectomy breast reconstruction
Experimental: Congenital malformations
Experimental: Breast Ptosis
Experimental: Micromastia
Experimental: Asymmetric Breasts

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	17 Years Kwa 17 Years
Jinsia Inastahiki Kujifunza	Female
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - Women with the following conditions micromastia, breast ptosis, post mastectomy breast reconstruction, asymmetric breasts, congenital malformations of breast development and for treatment of complications associated with implant augmentation mammoplasty. Exclusion Criteria: - A volunteer who has a positive pregnancy test - A volunteer who has had a cardiac stent placed within the last two months - A volunteer with a known, current substance abuse - A volunteer with a bleeding diathesis - Untreated breast cancer - A volunteer who smokes cigarettes - Medical Conditions including untreated hypertension, renal disease, diabetes mellitus

Matokeo

Hatua za Matokeo ya Msingi

1. 3 Dimensional volumetric analysis of results and photographic analysis by board certified plastic surgeons. [3 months, 6 months and annually]

Hatua za Matokeo ya Sekondari

1. Patient satisfaction with cosmetic and reconstructive results [3 months, 6 months and annually]