Beta Glucan and Acetate Production
Maneno muhimu
Kikemikali
Tarehe
| Imethibitishwa Mwisho: | 09/30/2018 |
| Iliyowasilishwa Kwanza: | 07/05/2018 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 10/17/2018 |
| Iliyotumwa Kwanza: | 10/21/2018 |
| Sasisho la Mwisho Liliwasilishwa: | 01/09/2020 |
| Sasisho la Mwisho Lilichapishwa: | 01/12/2020 |
| Tarehe halisi ya kuanza kwa masomo: | 09/04/2018 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 05/09/2019 |
| Tarehe ya Kukamilisha Utafiti: | 05/09/2019 |
Hali au ugonjwa
Uingiliaji / matibabu
Dietary Supplement: beta glucan and Resistant Starch
Dietary Supplement: Placebo
Dietary Supplement: beta glucan
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Placebo Comparator: Placebo | Dietary Supplement: Placebo isocaloric maltodextrin before the CID |
| Active Comparator: beta glucan | Dietary Supplement: beta glucan 12 g beta gluten there day before the CID |
| Experimental: beta glucan and Resistant Starch | Dietary Supplement: beta glucan and Resistant Starch 12g per day the day before the CID Resistant starch 7.5 g |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 30 Years Kwa 30 Years |
| Jinsia Inastahiki Kujifunza | Male |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - lean (BMI ≥ 20kg/m2 and ≤ 24.9kg/m2) - normoglycemic - aged 30 - 65 years OR - overweight/obese (BMI ≥ 25kg/m2 and ≤ 34.9kg/m2) - pre-diabetes - aged between 30 - 65 years. Exclusion Criteria: - diabetes mellitus - gastroenterological diseases or major abdominal surgery (allowed i.e.: ---appendectomy, cholecystectomy) - lactose intolerance and other digestive disorders - cardiovascular disease, cancer, liver or kidney malfunction (determined based on ALAT and creatinine levels, respectively) - disease with a life expectancy shorter than 5 years - Use of antibiotics 3 months prior inclusion - Use of probiotics or prebiotics |
Matokeo
Hatua za Matokeo ya Msingi
1. Plasma acetate concentrations (microM) [at baseline (before a high-fat mixed meal)]
2. Plasma acetate concentrations (microM) [four hours after a high fat mixed meal]
Hatua za Matokeo ya Sekondari
1. Energy expenditure (kJ/min) will be measured using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands) [at baseline and four hours after a high fat mixed meal]
2. fat oxidation (g/min) will be measured using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands) [at baseline and four hours after a high fat mixed meal]
3. carbohydrate oxidation (g/min) will be measured using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands) [at baseline and four hours after a high fat mixed meal]
4. Circulating hormone concentrations (Insulin, GLP-1, PYY) [at baseline and four hours after a high fat mixed meal]
5. Circulating metabolite concentrations (Glucose, Free Fatty Acids, Triglycerides) [at baseline and four hours after a high fat mixed meal]
6. Plasma glucose (mmol/L) [at baseline and four hours after a high fat mixed meal]
7. Free Fatty Acids (micromol/L) [at baseline and four hours after a high fat mixed meal]
8. Breath H2 using (Bedfont EC60 Gastrolyzer, Rochester, UK) [at baseline and four hours after a high fat mixed meal]
