Biomarkers of Common Eye Diseases
Maneno muhimu
Kikemikali
Maelezo
The pathogenesis of common eye diseases such as uveitis (including Behcet's disease (BD) and Vogt-Koyanagi-Harada disease (VKH)), diabetic retinopathy (DR), age-related macular degeneration (AMD) and polypoid choroidal vasculopathy (PCV) remains unknown. Although immunosuppressants, anti-vascular endothelial growth factor (VEGF) agents, and pars plana vitrectomy (PPV) have been widely used for treatment, the current therapeutic options are limited. In addition, there is a lack of biomarkers to indicate the prognosis and treatment response of these diseases. The aim of this study is to identify biomarkers and to provide a new target for individualized diagnosis and treatment of common eye diseases based on single cell sequencing technology.
Tarehe
| Imethibitishwa Mwisho: | 08/31/2019 |
| Iliyowasilishwa Kwanza: | 09/19/2019 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 09/22/2019 |
| Iliyotumwa Kwanza: | 09/23/2019 |
| Sasisho la Mwisho Liliwasilishwa: | 09/24/2019 |
| Sasisho la Mwisho Lilichapishwa: | 09/26/2019 |
| Tarehe halisi ya kuanza kwa masomo: | 09/25/2019 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 09/30/2020 |
| Tarehe ya Kukamilisha Utafiti: | 09/30/2021 |
Hali au ugonjwa
Uingiliaji / matibabu
Other: Collection of blood samples
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Patients with VKH, BD, DR, AMD, or PCV Collection of blood samples and clinical information from patients with VKH, BD, DR, AMD, or PCV | |
| Healthy subjects Collection of blood samples and clinical information |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Njia ya sampuli | Non-Probability Sample |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria for patients: 1. Age over 18 (including 18 years old); 2. Clinically diagnosed as diabetic retinopathy (DR), uveitis (VKH or BD) , age-related macular degeneration (AMD) , or polypoid choroidal vasculopathy (PCV) Exclusion Criteria for patients with retinal diseases: 1. Have received more than 2 intravitreal injections of anti-VEGF drugs because of retinal or choroidal neovascularization and macular edema; 2. Patients with stable condition after having undergone panretinal laser photocoagulation and pars plana vitrectomy (PPV); 3. There are other serious systemic diseases of the body, such as history of chronic kidney disease requiring dialysis or a kidney transplant, unstable blood pressure, cardiovascular disease, tumors, etc; 4. Patients who are pregnant or nursing |
Matokeo
Hatua za Matokeo ya Msingi
1. Peripheral blood mononuclear cell (PBMC) signatures [1 year]
Hatua za Matokeo ya Sekondari
1. PBMC cell types frequencies [1 year]
