Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
Maneno muhimu
Kikemikali
Maelezo
The combination of acute infection and a low level of oxygen in the blood is a common phenomenon. Thus, acute hypoxia may complicate severe infections including severe sepsis. Conversely, healthy persons who ascend to moderately high altitudes, which will be associated with a lowering of the inspired oxygen level, may sustain an infection. Even so, it is unknown whether hypoxia modifies the systemic inflammatory response, or, conversely, whether the reaction to hypoxia is influenced by the presence of systemic inflammation. The present protocol aims to measure global cerebral blood flow, metabolism and net flux as well as the systemic response in healthy volunteers who are subjected to either normobaric hypoxia alone (N=12), low-dose IV endotoxin infusion alone (N=12), or a combination of endotoxin infusion and normobaric hypoxia (N=12).
Tarehe
Imethibitishwa Mwisho: | 08/31/2008 |
Iliyowasilishwa Kwanza: | 05/30/2006 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 05/30/2006 |
Iliyotumwa Kwanza: | 05/31/2006 |
Sasisho la Mwisho Liliwasilishwa: | 09/01/2008 |
Sasisho la Mwisho Lilichapishwa: | 09/03/2008 |
Tarehe halisi ya kuanza kwa masomo: | 04/30/2006 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 06/30/2006 |
Tarehe ya Kukamilisha Utafiti: | 06/30/2006 |
Hali au ugonjwa
Uingiliaji / matibabu
Procedure: Endotoxin infusion, Normobaric hypoxia
Awamu
Vigezo vya Kustahiki
Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
Jinsia Inastahiki Kujifunza | Male |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - Healthy nonsmoking male - Age 18-45 yrs Exclusion Criteria: |
Matokeo
Hatua za Matokeo ya Msingi
1. Cerebral blood flow [0, 9 hours]
2. Cerebral oxygen metabolism [0, 9 hours]
3. Plasma cytokine content [0, 4, 19, 12 hours]
4. Lake Louise Score [0, 4, 9, 12 hours]
5. ESQ-C [0, 4, 9, 12 hours]
6. Endotoxemia Score [0, 4, 9, 12 hours]
Hatua za Matokeo ya Sekondari
1. Cerebral net flux [0, 9 hours]
2. Mean arterial pressure [Hourly, 0 through 12 hours]
3. Heart rate [Hourly, 0 through 12 hours]
4. Oxygen saturation [Hourly, 0 through 12 hours]
5. Body temperature [Hourly, 0 through 12 hours]