Confocal Laser Endomicroscopy in Digestive Diseases

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

Hali

Wadhamini

Chinese PLA General Hospital

JARIBIO LA KLINIKI: NCT01156064

BioSeek: nct01156064

Maneno muhimu

Kikemikali

Confocal laser endomicroscopy (CLE) is a newly endoscopic device that enables microscopic view of the digestive tract. The purpose of this study is to determine if confocal laser endomicroscopy can improve detection of digestive disease include inflammation, dysplasia, and early cancer, and if confocal laser endomicroscopy has competitive advantage, compared with other device such as Narrow Band Imaging and Autofluoresecence Imaging.

Maelezo

Advances in endoscopy have led to imagining of the details of digestive mucosa. Novel techniques such as Narrow Band Imaging (NBI) assisted magnification endoscopy, Auto Fluorescence Imaging (AFI) or confocal laser endomicroscopy could, however, improve the endoscopic detection.In this research we describe the combined use of these three techniques in patients with digestive disease.

Tarehe

Imethibitishwa Mwisho:	06/30/2010
Iliyowasilishwa Kwanza:	06/28/2010
Uandikishaji uliokadiriwa Uliwasilishwa:	06/30/2010
Iliyotumwa Kwanza:	07/01/2010
Sasisho la Mwisho Liliwasilishwa:	11/21/2010
Sasisho la Mwisho Lilichapishwa:	11/22/2010
Tarehe halisi ya kuanza kwa masomo:	07/31/2008
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	11/30/2009
Tarehe ya Kukamilisha Utafiti:	11/30/2011

Hali au ugonjwa

Digestive System Diseases

Uingiliaji / matibabu

Device: Confocal Laser Endomicroscopy (Pentax/Optiscan)

Device: Narrow Band Imaging/Auto Fluorescence Imaging (Olympus)

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Case (subjects with digestive diseases) The investigators cases are subjects with confirmed digestive diseases.
Control Healthy individuals aged between 18 and 90 years who are asymptomatic for digestive diseases.

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Years Kwa 18 Years
Jinsia Inastahiki Kujifunza	All
Njia ya sampuli	Non-Probability Sample
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - Subjects over 18 years of age - Subjects undergoing endoscopic procedures such as gastroscopy, colonoscopy, endoscopic retrograde cholangiopancreatography and endoscopic ultrasound will all be included Exclusion Criteria: - Under 18 years of age. - Pregnancy or breast feeding - Allergy to the fluorescent contrast agent fluorescein sodium - Coagulopathy or bleeding disorder - In emergency or life-threatening situations(eg. acute gastrointestinal hemorrhage, and gastrointestinal obstruction or perforation) - impaired renal function, allergic asthma, - Cognitively impaired. - Residing in institutions (eg. prison, extended care facility) - Have language barriers (eg. illiterate, dysphasic)

Matokeo

Hatua za Matokeo ya Msingi

1. Diagnostic yield for neoplasia of CLE vs. standard endoscopy [one year]

Hatua za Matokeo ya Sekondari

1. Diagnostic yield for neoplasia of CLE vs. NBI/AFI [one year]