Derris Scandens Benth Extract VS Naproxen in Knee OA
Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Kiungo kimehifadhiwa kwenye clipboard
HaliImekamilika
Wadhamini
Mahidol University
Washirika
Ministry of Health, Thailand
JARIBIO LA KLINIKI: NCT00503828
BioSeek: nct00503828
Maneno muhimu
Kikemikali
Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.
Tarehe
| Imethibitishwa Mwisho: | 05/31/2009 |
| Iliyowasilishwa Kwanza: | 07/17/2007 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 07/17/2007 |
| Iliyotumwa Kwanza: | 07/18/2007 |
| Sasisho la Mwisho Liliwasilishwa: | 01/10/2010 |
| Sasisho la Mwisho Lilichapishwa: | 01/12/2010 |
| Tarehe halisi ya kuanza kwa masomo: | 06/30/2007 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 02/28/2009 |
| Tarehe ya Kukamilisha Utafiti: | 02/28/2009 |
Hali au ugonjwa
Knee Osteoarthritis
Uingiliaji / matibabu
Drug: Derris Scandens Benth
Drug: naproxen
Awamu
Awamu 3
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Active Comparator: naproxen Naproxen 500 mg/day for 4 weeks | Drug: naproxen Naproxen 500 mg/day for 4 weeks |
| Experimental: Derris Scandens Benth Derris Scandens Benth | Drug: Derris Scandens Benth Derris scandens Benth extracts (oral) 400 mg twice per day for 4 weeks |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 50 Years Kwa 50 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Age >=50 yr - Known case of primary knee osteoarthritis - WOMAC pain subscale (item1) >= 5 - signed informed consent Exclusion Criteria: - hypersensitive to NSAIDs - history of peptic ulcer or melena - unable to walk , i.e. patient with severe spinal stenosis, myocardial infarction - history of intra-articular injection of knee within 3 months - status post knee replacement |
Matokeo
Hatua za Matokeo ya Msingi
1. WOMAC score [2, 4 weeks]
Hatua za Matokeo ya Sekondari
1. 6-minute walk, Quality of Life, adverse event [2, 4 weeks]
