Dietary Fiber Intake in Alcohol-dependent Patients
Maneno muhimu
Kikemikali
Tarehe
Imethibitishwa Mwisho: | 11/30/2018 |
Iliyowasilishwa Kwanza: | 12/12/2018 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 01/09/2019 |
Iliyotumwa Kwanza: | 01/14/2019 |
Sasisho la Mwisho Liliwasilishwa: | 02/04/2019 |
Sasisho la Mwisho Lilichapishwa: | 02/06/2019 |
Tarehe halisi ya kuanza kwa masomo: | 07/03/2017 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 06/30/2022 |
Tarehe ya Kukamilisha Utafiti: | 06/30/2022 |
Hali au ugonjwa
Uingiliaji / matibabu
Dietary Supplement: inulin
Dietary Supplement: placebo
Awamu
Vikundi vya Arm
Mkono | Uingiliaji / matibabu |
---|---|
Placebo Comparator: placebo maltodextrin received at 4g/day on day 3 and 4
maltodextrin received at 8g/day from day 5 to 14
maltodextrin received at 16g/day from day 15 to 20 | Dietary Supplement: placebo maltodextrine given at different dosis from day 3 to day 20 |
Experimental: inulin inulin received at 4g/day on day 3 and 4
inulin received at 8g/day from day 5 to 14
inulin received at 16g/day from day 15 to 20 | Dietary Supplement: inulin inulin given at different dosis from day 3 to day 20 |
Vigezo vya Kustahiki
Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
Jinsia Inastahiki Kujifunza | All |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - male or female - aged between 18 and 65 - caucasian - French speaking - alcohol drunk less than 48h before day 1 Exclusion Criteria: - another addiction, except smoking - psychiatric comorbidity on axe 1 of Diagnostic and Statistical Manual-IV - antibiotic, probiotic or fibers recent (<2 months) treatment (or other molecule modifying intestinal transit) - Non-steroidial anti-inflammatory drug or glucocorticoids recently taken (<1 month) - obesity: Body Mass Index<30 - bariatric surgery - Type 1 or 2 diabetes - chronic inflammatory diseases (Crohn disease, coeliac disease, rheumatoid arthritis) - cirrhosis or Advanced hepatic fibrosis (Fibroscan > or = F3) - pregnancy |
Matokeo
Hatua za Matokeo ya Msingi
1. Change in diet profile [on Day 2 and Day 19]
Hatua za Matokeo ya Sekondari
1. Alimentary book [From day 1 to day 21]
2. Quantitative evaluation of intakes [on Day 2 and Day 19]
3. Alimentation history [On day 21]
4. Change in mood [on Day 2 and Day 19]
5. Change in anxiety [on Day 2 and Day 19]
6. Change in alcohol craving [on Day 2 and Day 19]
7. Change in impulsivity [on Day 2 and Day 19]
8. Change in selective attention [on Day 2 and Day 19]
9. Change in work memory [on Day 2 and Day 19]
10. Change in flexibility [on Day 2 and Day 19]
11. Change in inhibition [on Day 2 and Day 19]
12. Change in decision making [on Day 2 and Day 19]
13. Change in trauma [on Day 2 and Day 19]
14. Change in intestine integrity [on Day 2 and Day 19]
15. Change in albumin, pre-albumin and zinc concentration [on Day 2 and Day 19]
16. Change in intestinal permeability [on Day 2 and Day 19]
17. Change in fecal albumin concentration [on Day 2 and Day 19]
18. Intestinal permeability [On day 3]