Do Antidepressants Induce Metabolic Syndromes METADAP Study
Maneno muhimu
Kikemikali
Maelezo
Since antidepressants and antipsychotics have common receptorial mechanisms of action (H1 antagonism, 5HT2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern.
The main objective of this study is to assess the differential impact of antidepressants in terms of weight gain and metabolic syndromes.
Prospective 6-month naturalistic cohort study, comparing 4 classes of antidepressants (SSRIs, SNRIs, TCAs and others) to a control group (ECT and r-TMS), in 600 patients with a major depressive disorder requiring the beginning of either antidepressant or ECT/r-TMS treatment.
Tarehe
| Imethibitishwa Mwisho: | 08/31/2007 |
| Iliyowasilishwa Kwanza: | 09/04/2007 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 09/06/2007 |
| Iliyotumwa Kwanza: | 09/09/2007 |
| Sasisho la Mwisho Liliwasilishwa: | 04/15/2014 |
| Sasisho la Mwisho Lilichapishwa: | 04/16/2014 |
| Tarehe halisi ya kuanza kwa masomo: | 10/31/2007 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 03/31/2013 |
| Tarehe ya Kukamilisha Utafiti: | 03/31/2013 |
Hali au ugonjwa
Uingiliaji / matibabu
Drug: Tricyclic antidepressants
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Experimental: A antidepressant versus medical dispositive | |
| Placebo Comparator: B |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Age : 18-70 - Current major depressive episode (Major depressive disorder) based on the MINI interview - HAM-D >18 - Requiring either antidepressant treatment, either ECT or r-TMS (as assessed by the clinician) - Signed informed consent Exclusion Criteria: - Bipolar disorder (DSM-IV), Psychotic disorder (DSM-IV), Substance abuse or dependence (DSM-IV) - Normothymic treatment - Antipsychotic treatment |
Matokeo
Hatua za Matokeo ya Msingi
1. Definition criteria of the metabolic syndromes: Weight and waist circumference Systolic and diastolic blood pressure Glycemia Triglyceridemia Cholesterolemia Insulinemia [at Months 0, 1, 3, 6]
Hatua za Matokeo ya Sekondari
1. Antidepressant efficacy (HAM-D, quickIDS-C, quickIDS-SR, CGI) [at Months 0, 1, 3, 6]
