Effect of Casodex on Tumour Hypoxia - Prostate Cancer

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliInatumika, sio kuajiri

Wadhamini

University Health Network, Toronto

Washirika

Canadian Cancer Trials Group

Princess Margaret Hospital, Canada

JARIBIO LA KLINIKI: NCT00188708

BioSeek: nct00188708

Maneno muhimu

Kikemikali

Prostate cancers, in common with many other tumours, are often hypoxic; that is, they have low levels of oxygen. It is thought that tumour hypoxia may hasten the progression of cancers and make them more resistant to treatment. One previous study has suggested that hormone therapy, such as Casodex, may improve the prostate oxygen level. This study is designed to test that finding.

Tarehe

Imethibitishwa Mwisho:	08/31/2020
Iliyowasilishwa Kwanza:	09/11/2005
Uandikishaji uliokadiriwa Uliwasilishwa:	09/11/2005
Iliyotumwa Kwanza:	09/15/2005
Sasisho la Mwisho Liliwasilishwa:	08/31/2020
Sasisho la Mwisho Lilichapishwa:	09/02/2020
Tarehe halisi ya kuanza kwa masomo:	03/31/2001
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	03/31/2021
Tarehe ya Kukamilisha Utafiti:	03/31/2021

Hali au ugonjwa

Prostatic Neoplasms

Uingiliaji / matibabu

Procedure: hypoxia measurement

Awamu

Awamu 2

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Experimental: hypoxia measurement Patients undergoing or planning to receive combined anti-androgen (Casodex) and radiotherapy	Procedure: hypoxia measurement transrectal oxygen measurement

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Years Kwa 18 Years
Jinsia Inastahiki Kujifunza	Male
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - Men with histologically proven prostatic carcinoma, stage cT2, N0, M0, receiving neoadjuvant bicalutamide plus conformal radiotherapy in study 9907, who have previously participated in the prostate cancer hypoxia project - informed consent Exclusion Criteria: - Coagulopathy

Matokeo

Hatua za Matokeo ya Msingi

1. To determine the effect of neoadjuvant anti-androgen therapy on oxygenation of prostatic tumours [8 weeks]

Trans-rectal ultrasound and measurement of tumor oxygenation

2. Correlate level of tumor oxygenation with PSA level [8 weeks]

PSA test (ug/L)

3. Correlate level of tumor oxygenation with hemoglobin level [8 weeks]

hemoglobin test (g/L)

4. Correlate level of tumor oxygenation with prostate volume [8 weeks]

prostate volume measurement

Hatua za Matokeo ya Sekondari

1. To study of the effect of neoadjuvant anti-androgen therapy on prostate tumour histopathology and gene expression, and correlation of these effects with changes in oxygenation. [8 weeks]