Effect of Garlic on Inflammatory Mediators
Maneno muhimu
Kikemikali
Maelezo
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
Tarehe
| Imethibitishwa Mwisho: | 02/28/2007 |
| Iliyowasilishwa Kwanza: | 01/09/2006 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 01/09/2006 |
| Iliyotumwa Kwanza: | 01/11/2006 |
| Sasisho la Mwisho Liliwasilishwa: | 03/18/2007 |
| Sasisho la Mwisho Lilichapishwa: | 03/19/2007 |
| Tarehe halisi ya kuanza kwa masomo: | 03/31/2006 |
| Tarehe ya Kukamilisha Utafiti: | 02/28/2007 |
Hali au ugonjwa
Uingiliaji / matibabu
Drug: Garlic Oil Macerate
Awamu
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - 18 years of age and older - Normal subjects with BMI <25, obese subjects with BMI >30 - Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws. Exclusion Criteria: - Subjects on any antioxidant medication. - Patient on non-steroidal anti-inflammatory drug. - On any agent with antioxidant properties. - History of drug or alcohol abuse. - Any life threatening disease. - On any agent with significant antioxidant properties. - Taking garlic extracts in the diet regularly. |
Matokeo
Hatua za Matokeo ya Msingi
1. 1. To examine the pharmacokinetics of the garlic oil macerate. [undefined]
Hatua za Matokeo ya Sekondari
1. 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level. [undefined]
