Effects of Alkaline Phosphatase on Renal Function in Septic Patients

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliImekamilika

Wadhamini

Radboud University

JARIBIO LA KLINIKI: NCT00457613

BioSeek: nct00457613

Maneno muhimu

Kikemikali

Septic shock is the most common cause of death in patients requiring intensive care. The kidney is one of the first organs to fail, stressing the importance to search for clinical interventions that may protect the kidneys during sepsis.

Alkaline phosphatase functions as a host defence molecule and is present in many cells and organs (e.g. intestine, placenta, liver, kidney and bone). Alkaline phosphatase has a dual mode of action. First, it binds to and, subsequently, dephosphorylates lipopolysaccharide (LPS). Second, the enzymatic reaction product monophosphoryl-LPS is a non-toxic substance for mammals which acts as a partial antagonist on the LPS receptor complex. In several animal studies, administration of alkaline phosphatase attenuates the inflammatory response and reduces mortality.

It is unknown whether these results can be extrapolated to septic patients . We studied the effects of alkaline phosphatse administration on kidney damage and function in patients with severe sepsis or septic shock.

Tarehe

Imethibitishwa Mwisho:	02/28/2006
Iliyowasilishwa Kwanza:	04/03/2007
Uandikishaji uliokadiriwa Uliwasilishwa:	04/04/2007
Iliyotumwa Kwanza:	04/05/2007
Sasisho la Mwisho Liliwasilishwa:	04/04/2007
Sasisho la Mwisho Lilichapishwa:	04/05/2007
Tarehe halisi ya kuanza kwa masomo:	10/31/2004
Tarehe ya Kukamilisha Utafiti:	02/28/2006

Hali au ugonjwa

Severe

Septic

Shock

Uingiliaji / matibabu

Drug: bolus injection, followed by a continuous infusion ( 24 h) (Alkaline phosphatase)

Awamu

Awamu 2

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Years Kwa 18 Years
Jinsia Inastahiki Kujifunza	All
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - Written informed consent - Proven or suspected Gram-negative bacterial infection - Two out of four Systemic Inflammatory Response Syndrome (SIRS) criteria existing for less than 24 h - Acute onset of end-organ dysfunction in the preceding 12 h Exclusion Criteria: - Prior therapy with alkaline phosphatase - Known allergy for cow milk - Probable death within 24 h - Chronic renal failure requiring hemodialysis or peritoneal dialysis - Acute pancreatitis with no established source of infection - HIV seropositive - Pregnant or lactating - Confirmed Gram-positive or fungal sepsis - Treatment with immunosuppressants including high doses of glucocorticosteroids

Matokeo

Hatua za Matokeo ya Msingi

1. Biomarkers of kidney damage [undefined]

2. kidney function [undefined]

3. markers of inflammation [undefined]

Effects of Alkaline Phosphatase on Renal Function in Septic Patients

Maneno muhimu

phosphatase

sepsisi

inflammation

alkaline phosphatase