Fatty Acid Biomarkers of Carbohydrate Intake
Maneno muhimu
Kikemikali
Maelezo
In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.
Tarehe
| Imethibitishwa Mwisho: | 10/31/2018 |
| Iliyowasilishwa Kwanza: | 09/21/2017 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 09/21/2017 |
| Iliyotumwa Kwanza: | 09/26/2017 |
| Sasisho la Mwisho Liliwasilishwa: | 11/13/2018 |
| Sasisho la Mwisho Lilichapishwa: | 11/14/2018 |
| Tarehe halisi ya kuanza kwa masomo: | 10/24/2017 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 05/31/2018 |
| Tarehe ya Kukamilisha Utafiti: | 05/31/2018 |
Hali au ugonjwa
Uingiliaji / matibabu
Other: Low carbohydrate diet
Other: High carbohydrate, high sugar diet
Other: High carbohydrate, low sugar diet
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Active Comparator: Fat - Sugar - Fiber Intervention: consuming diets rich in fat, rich in sugar, and rich in fibers during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Fat - Fiber - Sugar Intervention: consuming diets rich in fat, rich in fiber, and rich sugar during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Sugar - Fiber - Fat Intervention: Consuming diets rich in sugar, rich in fiber, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Sugar - Fat - Fiber Intervention: Consuming diets rich in sugar, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Fiber - Sugar - Fat Intervention: Consuming diets rich in fiber, rich in sugar, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Fiber - Fat - Sugar Intervention: consuming diets rich in fiber, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 20 Years Kwa 20 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - BMI 20-38 Exclusion Criteria: - abnormal lab tests (assessed by screening and judged by a physician), diabetes, cardiovascular, kidney, liver or malignant disease, and weight-loss (±3kg) the preceding 3 months of screening. Extreme diets, i.e. very-low carbohydrate diets, intermittent fasting, vegan diets or allergic to gluten |
Matokeo
Hatua za Matokeo ya Msingi
1. Palmitic acid in different plasma fractions [14-20 days]
Hatua za Matokeo ya Sekondari
1. Even-chain saturated fatty acids (i.e. 14:0, 18:0) and monounsaturated fatty acids [14-20 days]
Hatua Nyingine za Matokeo
1. Desaturation indices end lipogenic indices [14-20 days]
