Genetic Markers and Proliferative Diabetic Retinopathy
Maneno muhimu
Kikemikali
Maelezo
In a previous study (2011), investigators demonstrated a statistically significant relation between the Endothelial Lipase(EL) c.584C>T polymorphism and the occurrence of diabetic retinopathy in 396 french patients with diabetes type 2 (DT2) with a longitudinal follow-up.
Secondly (2014) in a subgroup of 287 DT2 patients, investigators showed the impact of the EL rare T allele was consistent with a recessive mode of inheritance, with homozygotes for the rare allele differing from the carriers of the major allele. Importantly, the homozygotes for the rare T allele were more likely to present with advanced stages of diabetic retinopathy (severe non proliferative and proliferative disease) and particularly with proliferative diabetic retinopathy (PDR).
Based on this model investigators decided to conduct a case-control prospective study comparing 155 french patients with DT2 with PDR (cases) and 155 french patients with DT2 without PDR (controls) on the basis of two genetic parameters: EL c.584C>T polymorphism that investigators previously studied and the C(-106)T aldose reductase polymorphism widely studied in diabetic retinopathy.
Tarehe
| Imethibitishwa Mwisho: | 04/30/2019 |
| Iliyowasilishwa Kwanza: | 08/21/2016 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 08/23/2016 |
| Iliyotumwa Kwanza: | 08/24/2016 |
| Sasisho la Mwisho Liliwasilishwa: | 05/20/2019 |
| Sasisho la Mwisho Lilichapishwa: | 05/22/2019 |
| Tarehe halisi ya kuanza kwa masomo: | 10/15/2013 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 04/15/2020 |
| Tarehe ya Kukamilisha Utafiti: | 03/31/2022 |
Hali au ugonjwa
Uingiliaji / matibabu
Genetic: genetic analysis
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Other: Diabetic patients with proliferative diabetic retinopathy | |
| Other: Diabetic patients with non proliferative diabetic retinopathy |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - type 2 diabetic patients - patient with proliferative diabetic retinopathy (for arm 1) - patient with non proliferative diabetic retinopathy (for arm 2) - patient older than 18 years - patient consenting to participate to the study - patient enrolled in the national healthcare insurance program |
Matokeo
Hatua za Matokeo ya Msingi
1. Proliferative retinopathy diabetic [Day 0]
