Giant Cell Arteritis: Improving Use of Ultrasound Evaluation
Maneno muhimu
Kikemikali
Maelezo
Objectives and Project Plan:
- Project Purpose:
The purpose of the project is to develop the technology to reliably acquire and analyse ultrasound images through the use of a training programme which are comparable to those from scanning by an expert sonographer in the diagnosis (i.e. as a diagnostic tool) and monitoring of patients with GCA following treatment (i.e. as a response indicator), and patient stratification according to initial or early scan changes to determine the most appropriate treatment (i.e. as a prognostic tool).
- End Point:
The end point will be the production of an effective training programme which can be used to obtain reproducible accurate ultrasound images of the temporal artery which can be automatically analysed and used in real time in the management of patients with suspected or confirmed giant cell arteritis.
- Milestones:
The project is in 3 phases. In phase 1 (0-12 months) the study group will create a bank of images for training from healthy volunteers and patients with GCA; in phase 2 (13-18 months) the study group will test the programme on sonographers assessing patients with GCA; in phase 3 (19-42 months) the study group will acquire serial images, clinical data, serum and plasma from cohorts of patients with newly diagnosed and flaring GCA so that they can analyse and develop new software algorithms. The study group can use images already acquired from a previous diagnostic study in GCA, and test the algorithms on the new cohorts..
Tarehe
Imethibitishwa Mwisho: | 07/31/2015 |
Iliyowasilishwa Kwanza: | 08/03/2015 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 08/11/2015 |
Iliyotumwa Kwanza: | 08/13/2015 |
Sasisho la Mwisho Liliwasilishwa: | 08/11/2015 |
Sasisho la Mwisho Lilichapishwa: | 08/13/2015 |
Tarehe halisi ya kuanza kwa masomo: | 09/30/2015 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 08/31/2017 |
Tarehe ya Kukamilisha Utafiti: | 05/31/2018 |
Hali au ugonjwa
Uingiliaji / matibabu
Device: Ultrasound of temporal and axillary arteries
Awamu
Vikundi vya Arm
Mkono | Uingiliaji / matibabu |
---|---|
Healthy volunteers Age and gender matched to patient groups to undergo ultrasound of temporal and axillary arteries | |
Patients with headache Patients with new headache not due to GCA to undergo ultrasound of temporal and axillary arteries | |
Patients with GCA (new) Patients with new diagnosis of GCA to undergo ultrasound of temporal and axillary arteries | |
Patients with GCA (flare) Patients with apparent flare of GCA to undergo ultrasound of temporal and axillary arteries |
Vigezo vya Kustahiki
Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
Jinsia Inastahiki Kujifunza | All |
Njia ya sampuli | Non-Probability Sample |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - Healthy volunteer or - Patient with a suspected diagnosis of GCA but found not to have GCA - Recent diagnosis of GCA within 1 month or - Suspected flare of GCA within one month - Ability to provide written informed consent Exclusion Criteria: - Unable to provide written informed consent |
Matokeo
Hatua za Matokeo ya Msingi
1. Size of halo detected (mm) on ultrasound of temporal arteries [24 months]
Hatua za Matokeo ya Sekondari
1. Circulating serum Vascular Endothelial Growth Factor (VEGF) levels [24 months]
2. Circulating serum Pentraxin 3 levels [24 months]