IBD Registry in a Sub-Saharan African Population
Maneno muhimu
Kikemikali
Maelezo
A prospective observational registry with a nested case-control study will be established at a gastrointestinal outpatient's clinic at a tertiary care hospital in Harare, Zimbabwe. The registry will recruit confirmed cases of inflammatory bowel disease from the clinic, other hospitals within and outside Harare, and from private practitioners. Two controls, a sibling or cousin, and an individual living in the same neighbourhood will also be recruited for each case. Demographic and clinical data will be obtained for all cases at baseline, after 6 months and annually thereafter. A questionnaire adapted from the International Organisation of IBD for risk factors of inflammatory bowel disease, and a food frequency questionnaire will be administered to all participants. Stool specimens, and germline DNA from peripheral blood will be biobanked in the Department of Medicine at the University of Zimbabwe. Preliminary data analysis will be carried out after at least 100 patients have been recruited. Descriptive statistics will be used to summarise data on demographic and phenotypic characteristics of inflammatory bowel disease, and incidence will be estimated for Harare. Risk factors for inflammatory bowel disease will be analysed using conditional logistic regression.
Tarehe
Imethibitishwa Mwisho: | 11/30/2019 |
Iliyowasilishwa Kwanza: | 11/24/2019 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 11/24/2019 |
Iliyotumwa Kwanza: | 11/25/2019 |
Sasisho la Mwisho Liliwasilishwa: | 12/01/2019 |
Sasisho la Mwisho Lilichapishwa: | 12/03/2019 |
Tarehe halisi ya kuanza kwa masomo: | 01/01/2020 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 12/30/2021 |
Tarehe ya Kukamilisha Utafiti: | 12/30/2025 |
Hali au ugonjwa
Uingiliaji / matibabu
Other: No intervention
Awamu
Vikundi vya Arm
Mkono | Uingiliaji / matibabu |
---|---|
Cases Cases of inflammatory bowel disease | |
Controls Two controls per case. 1. Sibling or other second degree relative of similar age. 2. neighbourhood control matched for age |
Vigezo vya Kustahiki
Jinsia Inastahiki Kujifunza | All |
Njia ya sampuli | Non-Probability Sample |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - Cases 1. Any patient with confirmed inflammatory bowel disease 2. Onset of disease ≥3 months ago. - Controls 1. Age ≥ 18 years (NB - cases younger than 18 will be excluded from case-control analysis 2. One sibling or cousin (2nd degree) and one neighbourhood control. Exclusion Criteria: - Cases 1. None - Controls 1. Suspected inflammatory bowel disease 2. Unexplained gastrointestinal symptoms including diarrhoea, vomiting, chronic abdominal pain, weight loss, rectal bleeding, and recent change in bowel habit. 3. Previous unexplained gastrointestinal surgery |
Matokeo
Hatua za Matokeo ya Msingi
1. Demographic and phenotypic features of inflammatory bowel disease [one year]
Hatua za Matokeo ya Sekondari
1. Risk factors of inflammatory bowel disease in Zimbabwe [Two years]
2. Dietary risk factors of inflammatory bowel disease in Zimbabwe [Two years]
3. Incidence and prevalence of inflammatory bowel disease in Zimbabwe [Three years]