Inflammatory Targeted Laser Treatment of Knee Osteoarthritis
Maneno muhimu
Kikemikali
Tarehe
| Imethibitishwa Mwisho: | 10/31/2018 |
| Iliyowasilishwa Kwanza: | 11/05/2018 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 11/19/2018 |
| Iliyotumwa Kwanza: | 11/22/2018 |
| Sasisho la Mwisho Liliwasilishwa: | 11/26/2018 |
| Sasisho la Mwisho Lilichapishwa: | 11/28/2018 |
| Tarehe halisi ya kuanza kwa masomo: | 04/18/2018 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 10/18/2020 |
| Tarehe ya Kukamilisha Utafiti: | 01/18/2021 |
Hali au ugonjwa
Uingiliaji / matibabu
Other: Exercise therapy
Other: Exercise therapy + LLLT
Other: Exercise therapy + sham LLLT
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Active Comparator: Exercise therapy + LLLT Exercise therapy 3 times per week for 8 weeks from baseline.
LLLT applied to the knee 3 times per week for 3 weeks from baseline. | Other: Exercise therapy + LLLT - LLLT (60 mW mean output per probe, 904 nm wavelength) applied to the knee in adherence with the recommendations by World Association for Laser Therapy, in terms of dosage per treatment spot. |
| Placebo Comparator: Exercise therapy + sham LLLT Exercise therapy 3 times per week for 8 weeks from baseline.
Sham LLLT applied to the knee 3 times per week for 3 weeks from baseline. | Other: Exercise therapy + sham LLLT - Same procedure as in the LLLT group with the exception of laser irradiation (0 mW mean output power). |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 50 Years Kwa 50 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion criteria: - Any gender - Age ≥ 50 years - Pain on movement ≥ 40 mm Visual Analog Scale - Knee pain for the last ≥ 3 months - KOA verified with the American College of Rheumatology criteria using a history and physical examination, i.e. knee pain and at least three of the following: ≥ 50 years old, ≤ 30 minutes of morning stiffness, crepitus on active range of motion, bony tenderness, bony enlargement, and no palpable warmth of synovia Exclusion criteria: - Knee alloplastic - Total meniscectomy - Intra-articular steroid injection and/or oral steroid treatment within the last six months - Cancer - Rheumatoid arthritis - Severe cognitive deficit - Neurological deficits affecting the knee - Inability to speak and understand English/Norwegian |
Matokeo
Hatua za Matokeo ya Msingi
1. Pain on movement [Change from baseline to week 3 and 8 and month 6 and 12]
2. Pain at night [Change from baseline to week 3 and 8 and month 6 and 12]
3. Pain at rest [Change from baseline to week 3 and 8 and month 6 and 12]
4. Pain in general [Change from baseline to week 3 and 8 and month 6 and 12]
Hatua za Matokeo ya Sekondari
1. Physical function in daily living [Change from baseline to week 3 and 8 and month 6 and 12]
2. Physical function in sports and recreational activities [Change from baseline to week 3 and 8 and month 6 and 12]
3. Quality of life [Change from baseline to week 3 and 8 and month 6 and 12]
4. Global health status assessment [Week 8]
5. Real time ultrasonography assessment of effusion [Change from baseline to week 3 and 8 and month 6 and 12]
6. Real time ultrasonography assessment of neovascularization [Change from baseline to week 3 and 8 and month 6 and 12]
7. Real time ultrasonography assessment of femur cartilage thickness [Change from baseline to week 3 and 8 and month 6 and 12]
8. 30 seconds chair stand [Change from baseline to week 3 and 8 and month 6 and 12]
9. Knee extension active range of motion [Change from baseline to week 3 and 8 and month 6 and 12]
10. Knee flexion active range of motion [Change from baseline to week 3 and 8 and month 6 and 12]
11. Maximum pain free isometric quadriceps strength [Change from baseline to week 3 and 8 and month 6 and 12]
12. Joint line pain pressure threshold [Change from baseline to week 3 and 8 and month 6 and 12]
13. Tibia bone pain pressure threshold [Change from baseline to week 3 and 8 and month 6 and 12]
14. Analgesic drug consumption due to knee pain [Change from baseline to week 3 and 8 and month 6 and 12]
