Inulin and Acetate Production and Human Substrate Metabolism
Maneno muhimu
Kikemikali
Tarehe
Imethibitishwa Mwisho: | 09/30/2018 |
Iliyowasilishwa Kwanza: | 07/05/2018 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 10/15/2018 |
Iliyotumwa Kwanza: | 10/17/2018 |
Sasisho la Mwisho Liliwasilishwa: | 01/09/2020 |
Sasisho la Mwisho Lilichapishwa: | 01/13/2020 |
Tarehe halisi ya kuanza kwa masomo: | 02/19/2018 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 11/14/2018 |
Tarehe ya Kukamilisha Utafiti: | 11/14/2018 |
Hali au ugonjwa
Uingiliaji / matibabu
Dietary Supplement: Inulin and Resistant Starch
Dietary Supplement: Inulin
Dietary Supplement: Placebo
Awamu
Vikundi vya Arm
Mkono | Uingiliaji / matibabu |
---|---|
Placebo Comparator: Placebo isocaloric maltodextrin the day before CIDs | Dietary Supplement: Placebo isocaloric maltodextrin before test day |
Active Comparator: Inulin 12 g of inulin + isocaloric maltodextrin the day before CID | Dietary Supplement: Inulin 12g per inulin in combination with maltodextrin per day the day before the CID |
Experimental: Inulin and Resistant Starch 12 g inulin + 7.5 g resistant starch the day before CID | Dietary Supplement: Inulin and Resistant Starch 12g per inulin in combination 7.5 g resistant starch per day the day before the CID Resistant starch 7.5 g |
Vigezo vya Kustahiki
Zama zinazostahiki Kujifunza | 30 Years Kwa 30 Years |
Jinsia Inastahiki Kujifunza | Male |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - lean (BMI ≥ 20kg/m2 and ≤ 24.9kg/m2) - normoglycemic - aged 30 - 65 years OR - overweight/obese (BMI ≥ 25kg/m2 and ≤ 34.9kg/m2) - pre-diabetes - aged between 30 - 65 years. Exclusion Criteria: - diabetes mellitus - gastroenterological diseases or major abdominal surgery (allowed i.e.: - appendectomy, cholecystectomy) - lactose intolerance and other digestive disorders - cardiovascular disease, cancer, liver or kidney malfunction (determined -based on ALAT and creatinine levels, respectively) - disease with a life expectancy shorter than 5 years - Use of antibiotics 3 months prior inclusion - Use of probiotics or prebiotics |
Matokeo
Hatua za Matokeo ya Msingi
1. Plasma acetate concentrations (microM) [At baseline and up to four hours after a high-fat mixed meal of each CID]
Hatua za Matokeo ya Sekondari
1. Energy expenditure (in kJ/min) using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands) [At baseline and up to four hours after a high-fat mixed meal of each CID]
2. Fat oxidation (in g/min) using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands) [At baseline and up to four hours after a high-fat mixed meal of each CID]
3. Carbohydrate oxidation (in g/min) using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands) [At baseline and up to four hours after a high-fat mixed meal of each CID]
4. Circulating hormone concentrations (Insulin, GLP-1, PYY) [At baseline and up to four hours after a high-fat mixed meal of each CID]
5. Circulating metabolite concentrations (Glucose, Free Fatty Acids, Triglycerides) [At baseline and up to four hours after a high-fat mixed meal of each CID]
6. Breath H2 using (Bedfont EC60 Gastrolyzer, Rochester, UK) [At baseline and up to four hours after a high-fat mixed meal of each CID]