Laparoscopic Versus Open Liver Resection for Hepatocellular Carcinoma
Maneno muhimu
Kikemikali
Maelezo
Liver resection is the most important treatment of hepatocellular carcinoma (HCC). Open hepatectomy was regarded as a giant surgery because of its big incision, influence of the liver function, and long hospital stay. Laparoscopic hepatectomy was widely used since it was reported by Reich in 1991. With the constant innovation of laparoscopic technique and equipment, there is no penalty area in laparoscopic hepatectomy. The Louisville consensus proposed that the best indication for laparoscopic hepatectomy was the tumor diameter < 5cm, located in segment II-VI.
Previous studies shows that compared with the open surgery, laparoscopic hepatectomy has the advantages of shorter operation time, less bleeding, shorter hospitalization time. The mortality, mobility, the overall survival and the disease-free survival was same in these two groups.
So far, however, the curative effect and safety research of laparoscopic versus open liver resection for HCC is limited to retrospective study and case-control study. A prospective, randomized, controlled study is urgently needed.
This study was proceeded to observe the curative effect and safety of laparoscopic versus open liver resection for HCC.
Tarehe
| Imethibitishwa Mwisho: | 01/31/2019 |
| Iliyowasilishwa Kwanza: | 08/04/2015 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 08/13/2015 |
| Iliyotumwa Kwanza: | 08/17/2015 |
| Sasisho la Mwisho Liliwasilishwa: | 02/10/2019 |
| Sasisho la Mwisho Lilichapishwa: | 02/11/2019 |
| Tarehe halisi ya kuanza kwa masomo: | 07/31/2015 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 05/31/2019 |
| Tarehe ya Kukamilisha Utafiti: | 11/30/2020 |
Hali au ugonjwa
Uingiliaji / matibabu
Procedure: laparoscopic hepatectomy
Procedure: Open hepatectomy
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Experimental: laparoscopic hepatectomy The HCC patients who meet the Louisville consensus will be underwent the liver resection by laparoscopic surgery | Procedure: laparoscopic hepatectomy The HCC patients who meet the Louisville consensus will underwent liver resection by laparoscopy |
| Experimental: Open hepatectomy The HCC patients who meet the Louisville consensus will be underwent the liver resection by open surgery | Procedure: Open hepatectomy The HCC patients who meet the Louisville consensus will underwent liver resection by open surgery |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: 1. Diagnosis was HCC 2. The tumor was located in segment: II, III, IVb, V, VI 3. The tumor diameter < 5cm 4. Without thrombosis in the portal vein, hepatic vein or bile duct 5. Without intrahepatic and systemic metastasis 6. The Child-pugh score was A-B7 7. The ASA（American Society of Anesthesiologists） score was I-III 8. The patient age was between 18-75 9. Sign the informed consent, and can fully understand the research content Exclusion Criteria: 1. Have surgery contraindications 2. Pregnant or lactating women 3. The Child-pugh score was B8-C 4. The ASA（American Society of Anesthesiologists） score was IV-V 5. With other malignant tumor 6. With mental illness 7. Participated in other clinical trials in the last three months 8. Underwent other treatments(chemotherapy or radiotherapy) before operation |
Matokeo
Hatua za Matokeo ya Msingi
1. Overall survival [5 years]
Hatua za Matokeo ya Sekondari
1. Disease free survival [5 years]
2. The duration of the operation [1 day]
3. The volume of blood loss during operation [1 day]
4. The volume of blood transfusion during operation [1 day]
5. Hospitalization days [7 days]
6. The total costs in hospital [7 days]
7. Total bilirubin measured after operation [7 days]
8. Alanine transaminase measured after operation [7 days]
9. Albumine measured after operation [7 days]
10. The volume of the drainage after operation [7 days]
11. The volume of pleural effusion after operation [7 days]
12. The volume of subphrenic collection after operation [7 days]
13. Change From Baseline in Pain on the 11 point Short Pain Scale (SPS-11) after operation [7 days]
14. The postoperative ECOG score [7 days]
