Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
Maneno muhimu
Kikemikali
Maelezo
The objective of this proposal is to adapt photoacoustic tomography (PAT), a novel, nonionizing, noninvasive, laser-based technology, for structural and functional imaging of human peripheral joints affected by inflammatory arthritis.
Combining the advantages of both light and ultrasound scanning, PAT holds promise to present objective optical information in subsurface joint tissues with high sensitivity and high spatial resolution.
This could be of considerable help in the early detection of inflammatory joint diseases. PAT may also prove useful in further understanding the pathophysiology of these disorders and assisting with therapeutic decisions, including assessment of new pharmacological therapies.
Tarehe
| Imethibitishwa Mwisho: | 12/31/2019 |
| Iliyowasilishwa Kwanza: | 09/03/2008 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 09/03/2008 |
| Iliyotumwa Kwanza: | 09/07/2008 |
| Sasisho la Mwisho Liliwasilishwa: | 01/13/2020 |
| Sasisho la Mwisho Lilichapishwa: | 01/17/2020 |
| Tarehe halisi ya kuanza kwa masomo: | 01/31/2008 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 12/31/2020 |
| Tarehe ya Kukamilisha Utafiti: | 12/31/2020 |
Hali au ugonjwa
Uingiliaji / matibabu
Procedure: Rheumatoid Arthritis
Procedure: Normal controls
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Rheumatoid Arthritis Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound | Procedure: Rheumatoid Arthritis Healthy subjects will have scans on finger joints with any of the scanning methods described above. |
| Normal controls Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand | Procedure: Normal controls Subjects with arthritis will have scans on finger joints with any of the scanning methods described above. |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Njia ya sampuli | Non-Probability Sample |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Men and women 18 years of age through age 60 can participate in this study. - Patients can participate in this study if they have had rheumatoid arthritis for more than 2 years and their rheumatologist has referred them to this study. - Patients can participate as a healthy volunteer with a known history of rheumatoid arthritis. Exclusion Criteria: - Patients, who have electrically, magnetically or mechanically activated implants such as heart pacemaker, magnetic surgical clips, prostheses or implanted neurological stimulator. - Pregnant patients. - Patients who is claustrophobic. - Patients with impaired renal function cannot participate in this study such as elevate creatinine clearance, patients on kidney dialysis etc. - Patients with shock hypotension or unstable low blood pressure. - Patients with Rhabdomyolysis. - Patients who have had a contrast enhanced (with gadolinium) MRA (magnetic resonance angiography)/ or MRI within the last 3 months. (Contrast is a medication injected into a vein during a imaging examination that helps produce clearer images/pictures). |
Matokeo
Hatua za Matokeo ya Msingi
1. Photoacoustic Imaging [2 weeks]
