Laser Therapy of Benign Thyroid Nodules

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

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Hali

Wadhamini

Odense University Hospital

JARIBIO LA KLINIKI: NCT00150150

BioSeek: nct00150150

Maneno muhimu

Kikemikali

Nodular goitre is common in the general population and less than 5% of the patients who undergo surgery for solitary thyroid nodules have cancer, in absence of clinical suspicion. Nodules left untreated seem to have a slight growth potential in borderline iodine-deficient areas. Interstitial laser photo-coagulation (ILP) is a procedure for local hyperthermia and photocoagulation, allowing minimally invasive treatment of benign tumors, including thyroid nodules. The aim of these studies are to evaluate if ILP will be useful in reducing the volume of the benign thyroid nodule and thyroid function will be unaffected in euthyroid patients, and normalized in pretoxic- and toxic thyroid nodules. The investigations are listed below:

1. Randomized study of interstitial laser photocoagulation for benign solitary cold thyroid nodules - one versus two or three treatments

2. Randomized study of interstitial laser photocoagulation for benign solitary autonomous thyroid nodules - 131I versus laser ablation

3. Interstitial laser photocoagulation for benign thyroid cystadenomas. - a feasibility study.

Tarehe

Imethibitishwa Mwisho:	02/28/2007
Iliyowasilishwa Kwanza:	09/05/2005
Uandikishaji uliokadiriwa Uliwasilishwa:	09/05/2005
Iliyotumwa Kwanza:	09/07/2005
Sasisho la Mwisho Liliwasilishwa:	03/25/2007
Sasisho la Mwisho Lilichapishwa:	03/26/2007
Tarehe halisi ya kuanza kwa masomo:	12/31/2000
Tarehe ya Kukamilisha Utafiti:	02/28/2006

Hali au ugonjwa

Benign Solitary Solid

Cystic Thyroid Nodules

Uingiliaji / matibabu

Procedure: Interstitial laser photocoagulation

Awamu

Awamu 3

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	20 Years Kwa 20 Years
Jinsia Inastahiki Kujifunza	All
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - Patients with a solitary solid thyroid nodule confirmed by ultrasonography - Patients with a solitary cystadenoma (cystic part more than 2 mL) confirmed by ultrasonography - Patients with an autonomous functioning thyroid nodule. Exclusion Criteria: - No family history of thyroid cancer - Prior radiation towards the neck - Fine needle biopsy without valid diagnostic criteria for benign thyroid disease - Nodules larger than 4 cm (largest diameter) - Suspicion of malignancy - Increased serum calcitonin - Pregnancy or lactation - Alcohol, medicine or drug abuse - No safe contraception - Physical or psychic condition that hinders corporation

Matokeo

Hatua za Matokeo ya Msingi

1. To evaluate the efficacy and feasibility repeated ILP treatments in a prospective randomised study where the nodule and thyroid volume are measured 1, 3, 6 and 12 months after the ILP. [undefined]

2. In the study of patients with a cystadenoma the measures will be done like wise, but also the recurrence of the cystic part will be measured. [undefined]

3. Patients with an autonomous functioning nodule measurements of thyroid function are performed 1,2, 3, 6, 9 and 12 months after the ILP or 131I therapy. [undefined]

Laser Therapy of Benign Thyroid Nodules

Maneno muhimu

thyroid nodule

saratani

cystadenoma

homa

goiter