Molecular Analysis of Childhood and Adolescent Melanocytic Lesions
Maneno muhimu
Kikemikali
Maelezo
Investigators will study the DNA and RNA in tumor cells and blood cells to look for changes that may be related to the development of the tumor, as well as changes that may influence how the tumor responds or doesn't respond to treatment. Normal blood cells will be studied to compare to the tumor cells. Investigators will also look at basic information about the treatment received and how the tumor responds, i.e. what kind of chemotherapy, surgery, radiation treatment, or other therapy the participant received, whether they had serious side effects, and how well the tumor responded to the treatment.
As part of regular medical care, tumor will be obtained to determine the type of cancer. For participants who consent to this study, leftover tumor tissue not needed for diagnosis or regular medical care will be studied at St. Jude Children's Research Hospital where scientists will look for changes in the genes of the tumor cells. No additional surgeries or procedures are needed for this study. A small amount of blood (2-3 tablespoons) will be collected and analyzed to determine if the genetic changes in the tumor cells are also found in the blood cells. Small children (<42 lbs.) will have a smaller amount drawn (1-2 tablespoons).
Tarehe
| Imethibitishwa Mwisho: | 03/31/2020 |
| Iliyowasilishwa Kwanza: | 05/11/2016 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 05/12/2016 |
| Iliyotumwa Kwanza: | 05/16/2016 |
| Sasisho la Mwisho Liliwasilishwa: | 04/01/2020 |
| Sasisho la Mwisho Lilichapishwa: | 04/05/2020 |
| Tarehe halisi ya kuanza kwa masomo: | 05/30/2016 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 05/30/2031 |
| Tarehe ya Kukamilisha Utafiti: | 05/30/2041 |
Hali au ugonjwa
Awamu
Vigezo vya Kustahiki
| Jinsia Inastahiki Kujifunza | All |
| Njia ya sampuli | Non-Probability Sample |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including: - Conventional or "adult-type" melanoma - Spitzoid melanoma/atypical Spitz tumor - Congenital melanoma - Melanoma arising in a giant congenital nevus - Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas) - Participant was <19 years of age at the time of diagnosis. - Tissue is available for biologic studies. - Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials. Exclusion Criteria: - Ocular melanoma - Inability or unwillingness of research participant or legal guardian to consent. - Histologic diagnosis other than melanocytic lesion described in 3.1.1. |
Matokeo
Hatua za Matokeo ya Msingi
1. Genomic profile [At participant enrollment]
Hatua za Matokeo ya Sekondari
1. Overall Survival (OS) [Up to 10 years following on-study date]
