Multidrug Resistant Shigella Infection in Bangladesh
Maneno muhimu
Kikemikali
Maelezo
2000 suspected Shigella cases will be recruited from International Centre for Diarrhoeal Disease Research hospital, Dhaka who are presenting with diarrhea at the hospital. A stool sample will be collected from the participants after consenting by the study staff. Stool microscopy will be performed to see the white blood cells(WBC) and red blood cells (RBC). If WBC > 10 HPF (4) with any RBC present, culture will be performed from this stool to identify Shigella. Such patients with invasive diarrhea are treated with azithromycin per local standard of care. Enrolled participant will be invited for further follow up when culture from the stool is Shigella positive. Minimal inhibitory concentration (MIC) testing of Shigella isolates and Molecular testing of Shigella isolates will be performed from Shigella cultures. This is an observational study. This study does not provide any treatment to the study participants; they will receive treatment as per International Centre for Diarrhoeal Disease Research Dhaka hospital guidelines. We will then examine the effect of the azithromycin minimal inhibitory concentration on clinical outcome.
Tarehe
| Imethibitishwa Mwisho: | 12/31/2018 |
| Iliyowasilishwa Kwanza: | 12/11/2018 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 12/12/2018 |
| Iliyotumwa Kwanza: | 12/18/2018 |
| Sasisho la Mwisho Liliwasilishwa: | 01/24/2019 |
| Sasisho la Mwisho Lilichapishwa: | 01/28/2019 |
| Tarehe halisi ya kuanza kwa masomo: | 12/12/2018 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 12/30/2019 |
| Tarehe ya Kukamilisha Utafiti: | 01/30/2020 |
Hali au ugonjwa
Awamu
Vigezo vya Kustahiki
| Jinsia Inastahiki Kujifunza | All |
| Njia ya sampuli | Probability Sample |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - diarrheal illness less than 96 hours duration - microscopic evidence of inflammatory diarrhea - plus mucus in stool - plus abdominal pain/cramps - Subject or parents or legal guardian willing to come for follow up at hospital or allow study staff for home visit - residence in Dhaka region - presentation during daytime hours Exclusion Criteria: • Not receiving treatment with azithromycin at enrolment |
Matokeo
Hatua za Matokeo ya Msingi
1. Clinical outcome: resolution of diarrhea [Day 5]
Hatua za Matokeo ya Sekondari
1. Microbiologic outcome: Shigella negative cultures [Day 5]
2. Proportion of patients that have complications [day 5]
Hatua Nyingine za Matokeo
1. time to last unformed stool [Day 5]
2. fever [Day 5]
3. bloody stool [Day 5]
4. difference in invasion plasmid antigen H (ipaH) [Day 5]
