Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema
Maneno muhimu
Kikemikali
Maelezo
To evaluate the effect of adding continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP) to standard medical therapy (ST) on intensive care unit (ICU) stay, hospital stay, mortality, need for endotracheal intubation, partial arterial O2 tension (PaO2), intrapulmonary shunt, alveolar-arterial (A-a) oxygen gradient, and cardiac output in patients admitted to the respiratory intensive care unit (ICU) or cardiac care unit (CCU) with acute CPE with gas exchange abnormalities and to evaluate the impact of heart failure type on the outcome of different therapeutic schedules.
Tarehe
| Imethibitishwa Mwisho: | 07/31/2009 |
| Iliyowasilishwa Kwanza: | 04/07/2009 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 04/08/2009 |
| Iliyotumwa Kwanza: | 06/02/2009 |
| Sasisho la Mwisho Liliwasilishwa: | 08/16/2009 |
| Sasisho la Mwisho Lilichapishwa: | 09/03/2009 |
| Tarehe ya matokeo ya kwanza yaliyowasilishwa: | 04/07/2009 |
| Tarehe ya matokeo ya kwanza ya QC yaliyowasilishwa: | 04/08/2009 |
| Tarehe ya matokeo ya kwanza kuchapishwa: | 06/02/2009 |
| Tarehe halisi ya kuanza kwa masomo: | 09/30/2003 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 10/31/2007 |
| Tarehe ya Kukamilisha Utafiti: | 10/31/2007 |
Hali au ugonjwa
Uingiliaji / matibabu
Other: ST
Device: CPAP + ST
Device: BiPAP + ST
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Active Comparator: CPAP + ST Continuous positive airway pressure (CPAP) and Standard medical therapy (ST) | Device: CPAP + ST Non-invasive mechanical ventilation (CPAP) |
| Active Comparator: BiPAP + ST Bilevel positive airway pressure (BiPAP) and standard medical therapy (ST) | Device: BiPAP + ST Non-invasive mechanical ventilation (BIPAP) |
| Active Comparator: ST Standard Medical therapy (ST) | Other: ST standard medical therapy |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: 1. CPE confirmed radiologically and/or clinically 2. Severe acute respiratory failure (partial arterial oxygen (PaO2)/Fraction of inspired oxygen (FIO2) less than 250) 3. Dyspnea of sudden onset with respiratory 4. Systolic blood pressure < 180 mmHg Exclusion Criteria: 1. Immediate need for endotracheal intubation: - Severe sensorial impairment - Shock - Ventricular arrhythmias, - Life-threatening hypoxia (SpO2 [oxygen saturation as indicated by pulse oximetry] less than 80% with oxygen) - Acute myocardial infarction necessitating thrombolysis - Cardiac or respiratory arrest 2. Severe chronic renal failure 3. Pneumothorax. 4. Contraindication of non invasive ventilation (NIV) |
Matokeo
Hatua za Matokeo ya Msingi
1. Number of Patients Who Were Intubated [During ICU Stay]
Hatua za Matokeo ya Sekondari
1. Arterial Blood Gases, Respiratory Rate, Blood Pressure, Cardiac Output ,Intrapulmonary Shunt, A-a Oxygen Gradient, Heart Rate, and Dyspnea Duration of Hospital and ICU Stay and Mortality [Hospital stay]
