Opioid Sparing General Venous Anesthesia With Magnesium Sulfate
Maneno muhimu
Kikemikali
Maelezo
Magnesium sulfate has been shown to be useful in many situations in medicine, such as eclampsia prevention and treatment, pulmonary hypertension, arterial pressure, asthma, cardiac arrhythmias and pheochromocytoma. Recently there has been a growing a big interest in this drug as an useful adjuvant in anesthesia, with analgesic and anesthetic sparing effect, antihyperalgesic property and potentialization of the neuromuscular blocker agent effect. On the other hand there has been a growing concern related to opioid administration, such as hyperalgesia, delayed return of intestinal function and the (still controversial) possibility of facilitating effect on tumor growth and metastases in cancer patients.
This project is based on a previous randomized, double blind prospective trial (conducted by one of these authors and not yet published) comparing two groups of patients who received general intravenous total anesthesia with propofol in controlled target infusion.
The surgical stress index is obtained by the interaction between the interval between heart beats and the amplitude of the photoplethysmography wave, whose algorithm generates a number related to the hemodynamic result of the increase of the sympathetic tone, which has shown to be the most sensitive resource in detecting the imbalance between the stimulus nociceptive and anti-nociception.
Objectives The main objective of this project is to evaluate the feasibility of the use of magnesium sulfate in replacement of remifentanil as the main analgesic agent in total venous general anesthesia in patients submitted to post-bariatric dermolipectomy surgery.
The secondary objectives will be comparison of propofol consumption, time to onset of action, time of action and cisatracurium consumption between groups. We will evaluate pain scores in the immediate postoperative period and in the mornings and afternoons of the 3 days after surgery.
Tarehe
Imethibitishwa Mwisho: | 10/31/2019 |
Iliyowasilishwa Kwanza: | 06/24/2019 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 06/30/2019 |
Iliyotumwa Kwanza: | 07/01/2019 |
Sasisho la Mwisho Liliwasilishwa: | 11/20/2019 |
Sasisho la Mwisho Lilichapishwa: | 11/24/2019 |
Tarehe halisi ya kuanza kwa masomo: | 09/30/2019 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 06/29/2022 |
Tarehe ya Kukamilisha Utafiti: | 06/29/2022 |
Hali au ugonjwa
Uingiliaji / matibabu
Drug: Remifentanil group
Drug: Magnesium group
Awamu
Vikundi vya Arm
Mkono | Uingiliaji / matibabu |
---|---|
Active Comparator: Remifentanil group Intravenous anesthesia with propofol and remifentanil | Drug: Remifentanil group Venous general anesthesia with propofol and remifentanil. |
Experimental: Magnesium group Intravenous anesthesia with propofol and magnesium sulfate | Drug: Magnesium group Venous general anesthesia with propofol and magnesium sulfate |
Vigezo vya Kustahiki
Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
Jinsia Inastahiki Kujifunza | All |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - age 18 to 60 year-old - body mass index < 35 kg/m² - American Society of Anesthesiologists score < III - agreement to participate and sign the informed consent form. Exclusion Criteria: - Allergy to any medications of the trial - neuromuscular diagnosed disorder - cardiac conduction blockade (atrioventricular block II or higher), - use of illicit drugs - use of calcium channel blockers - creatinine > 2 mg/dl. |
Matokeo
Hatua za Matokeo ya Msingi
1. Feasibility of using magnesium sulfate as analgesic of venous general anesthesia [Surgery time]
Hatua za Matokeo ya Sekondari
1. Anesthetic consumption. [During surgery]
2. Neuromuscular blocker action [During surgery]
3. Postoperative pain [Three days]