Paracetamol vs Metoclopramide on Postoperative Nausea and Vomiting
Maneno muhimu
Kikemikali
Maelezo
One hundred-twenty patients are randomly divided into two groups; the paracetamol group who received the IV infusion of paracetamol (1.5 ml/kg); and the metoclopramide group who received the IV infusion of metoclopramide (0.2 mg/kg) in saline. The presence of vomiting and the actions indicative of nausea, such as repeated gagging or spitting, within 24h following general anesthesia are defined as PONV. All PONV episodes and postoperative pain scores are recorded during 24h postoperatively. The postoperative 0-4h and 4-24h are defined as early and late postoperative period, respectively. Intravenous 4 mg ondansetron as rescue antiemetic drug is administered in case of two or more vomiting episodes.
Tarehe
| Imethibitishwa Mwisho: | 06/30/2018 |
| Iliyowasilishwa Kwanza: | 07/04/2018 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 07/04/2018 |
| Iliyotumwa Kwanza: | 07/16/2018 |
| Sasisho la Mwisho Liliwasilishwa: | 07/04/2018 |
| Sasisho la Mwisho Lilichapishwa: | 07/16/2018 |
| Tarehe halisi ya kuanza kwa masomo: | 07/19/2018 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 08/19/2018 |
| Tarehe ya Kukamilisha Utafiti: | 08/20/2018 |
Hali au ugonjwa
Uingiliaji / matibabu
Drug: Perfalgan
Drug: Metoclopramide
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Active Comparator: Perfalgan 1.5 mg/kg intravenous, intraoperative (20 min before end of the surgery) | |
| Active Comparator: Metoclopramide 0.2 mg/kg intravenous, intraoperative (20 min before end of the surgery) |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - ASA (the classification of the American Society of Anesthesiologists) physical status I-II - Patients who scheduled for elective maxillofacial surgery under general anesthesia Exclusion Criteria: - Patients with a history of allergy to any of the study medications (opioid, general anesthetic agents or paracetamol) - History of opioid use, hepatic or renal disease, coronary, psychotic and neurologic diseases - Use of antiemetic, antihistaminic, analgesic or corticosteroid 24 hours (h) prior to surgery |
Matokeo
Hatua za Matokeo ya Msingi
1. Preventing of postoperative nausea and vomiting [First 24 hours postoperatively]
