Post-occlusive Reactive Hyperemia and Basal-cell Carcinoma
Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Kiungo kimehifadhiwa kwenye clipboard
HaliImekamilika
Wadhamini
Institut Curie
JARIBIO LA KLINIKI: NCT01455363
BioSeek: nct01455363
Maneno muhimu
Kikemikali
The investigators aim to test the hypothesis and to proof thank to laser speckle contrast imaging that post-occlusive reactive hyperemia (PORH) can be induced through a tumor, in this case, through a basal cell carcinoma, which will be used as a model of study of tumor vasculature.
This new concept of tumor perfusion artificial increase could be used in the future for malignant tumors treatment, in order to increase tumor mean oxygen partial pressure (thus decreasing tumor hypoxia, hallmark of malignant tumors) during cancerology therapies, like radiotherapy and/or chemotherapy, and increase their efficacy.
This clinical trial will use skin flap model for trunk and facial basal cell carcinoma (BCC), with respect the classical excision margin of BCC surgery (3-4mm): after local anesthesia, a little random pattern skin flap will be raised around the BCC, then the cutaneous pedicle will be clamped with surgical clamp for 3 minutes and clamp released.
In case of limb BCC, limb tourniquet will be used, and occluded during 3 minutes upstream to the BCC location.
During all steps of experimentation, laser speckle imaging will be used to measure continuously the peri-tumoral and tumoral perfusion, start from tumor excision, up to10 minutes after tumor pedicle clamp or tourniquet release.
Tarehe
| Imethibitishwa Mwisho: | 08/31/2011 |
| Iliyowasilishwa Kwanza: | 10/09/2011 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 10/16/2011 |
| Iliyotumwa Kwanza: | 10/18/2011 |
| Sasisho la Mwisho Liliwasilishwa: | 04/02/2012 |
| Sasisho la Mwisho Lilichapishwa: | 04/03/2012 |
| Tarehe halisi ya kuanza kwa masomo: | 05/31/2011 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 09/30/2011 |
| Tarehe ya Kukamilisha Utafiti: | 09/30/2011 |
Hali au ugonjwa
Carcinoma, Basal Cell
Uingiliaji / matibabu
Procedure: BCC surgery
Other: Tourniquet ischemia
Other: Laser speckle imaging
Awamu
-
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Age ≥ 18 - Histologically proved cutaneous BCC - Patient being informed and having signed the consent to participate to the study Exclusion Criteria: - Counter-indication to surgery - Patient being unable to attend future follow-up visits - Patient with severe cognitive impairment - Patient not affiliated to a social security regimen - Patient with limb BCC and history of peripheral vascular artery surgery like bypass and/or vascular prothesis on the same limb (tourniquet counter-indication) - Local bone invasion of BCC detected with imagery |
Matokeo
Hatua za Matokeo ya Msingi
1. Evaluation of blood perfusion of tumor as ROI (Region Of Interest) [5 months]
Evaluation of blood perfusion of tumor as ROI (Region Of Interest)in unit of laser doppler perfusion, analyzed by the software Pimsoft with the imager laser doppler Pericam PSI system of Perimed.
