Resveratrol's Effects in Diabetic Nephropathy
Maneno muhimu
Kikemikali
Maelezo
Diabetes mellitus (DM) is one of the most important public health burdens, and its prevalence has rapidly increased worldwide over the past decades. One of the most important complications of DM is nephropathy.
Resveratrol (3, 5, 4'-trihydroxystilbene) is a natural polyphenolic compound belongs to the large group of polyphenols found in different plant species. The richest natural source of resveratrol is Polygonum cuspidatum — a plant root extract of which have been used in oriental folk medicine. Considerable amounts of resveratrol were also found in skin of red grapes, peanuts, groundnuts, and red vine.
Resveratrol is considered to have beneficial effects on glucose tolerance and insulin sensitivity, the cardiovascular system, as it has been found to improve vasodilatation, ischaemic preconditioning, both of which seem to be the result of the activation of the endothelial NO synthase enzyme, and to inhibit both platelet aggregation and vascular smooth muscle cell proliferation. Resveratrol itself is an efficient antioxidant, as evidenced by both in vitro and in vivo studies, and, it has also been shown to improve diabetes-related impairments in animals.
We hypothesized that resveratrol may have a favorable effects on control of diabetic nephropathy. The aim of this study is to evaluate the safety and effects of resveratrol in treatment of diabetic nephropathy.
Tarehe
| Imethibitishwa Mwisho: | 09/30/2017 |
| Iliyowasilishwa Kwanza: | 03/03/2016 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 03/05/2016 |
| Iliyotumwa Kwanza: | 03/09/2016 |
| Sasisho la Mwisho Liliwasilishwa: | 10/02/2017 |
| Sasisho la Mwisho Lilichapishwa: | 10/04/2017 |
| Tarehe halisi ya kuanza kwa masomo: | 02/29/2016 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 01/31/2017 |
| Tarehe ya Kukamilisha Utafiti: | 01/31/2017 |
Hali au ugonjwa
Uingiliaji / matibabu
Drug: Resveratrol
Drug: Placebo
Drug: Losartan
Awamu
Vikundi vya Arm
| Mkono | Uingiliaji / matibabu |
|---|---|
| Experimental: Resveratrol Resveratrol + Losartan | Drug: Resveratrol Resveratrol 500mg daily |
| Placebo Comparator: Placebo Placebo + Losartan | Drug: Placebo Placebo 1 capsule daily |
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | Inclusion Criteria: - Type 2 diabetes mellitus (DM) - Controlled blood sugar [fasting blood sugar (FBS) <130mg/dl and glycosylated hemoglobin (A1C)<7% - Urine albumin >20mg/lit in two separate occasions during the last 3 months period - Serum creatinin < or = 2mg/dl Exclusion Criteria: - Pregnancy - Lactation - Alcoholism - Liver failure (acute or chronic) - Renal failure: serum creatinin >2mg/dl - Glomerulonephritis - Uncontrolled hypertension - Congestive heart failure - Prostate disease - Malignancy - Bilateral renal artery stenosis - Any systemic disease other than DM - Any infection or rheumatologic disorder - Use of warfarin |
Matokeo
Hatua za Matokeo ya Msingi
1. Urine albumin level [3 months]
2. Serum creatinin [3 months]
Hatua za Matokeo ya Sekondari
1. Fasting blood sugar (FBS) [3 months]
2. Glycosylated hemoglobin (A1C) [3 months]
3. Liver aminotransferases (ALT and AST) [3 months]
4. Serum insulin level [3 months]
5. Number of patients with adverse events [3 months]
