Retinol on Human Skin Aging in East Asian Descent

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliImekamilika

Wadhamini

Stanford University

JARIBIO LA KLINIKI: NCT02906566

BioSeek: nct02906566

Maneno muhimu

kupambana na kuzeeka

Kikemikali

There has been increasing evidence for different rates of natural aging in humans and one of the best organs to study human aging is skin. Studies have demonstrated anti-aging effects of topical agents (such as creams, gels, lotions, or ointments) and one of them, retinol or vitamin A, was shown to decrease fine wrinkling in skin of older individuals. Additionally, studies of retinol in humans have largely occurred in white populations and so this study aims to focus on skin aging in individuals of East Asian descent as they represent a majority of the world population. This study aims to better characterize the molecular basis of rejuvenation effects and to potentially discover new topical agents with similar and/or more effective preservation of skin youthfulness.

Tarehe

Imethibitishwa Mwisho:	02/28/2019
Iliyowasilishwa Kwanza:	02/25/2016
Uandikishaji uliokadiriwa Uliwasilishwa:	09/13/2016
Iliyotumwa Kwanza:	09/19/2016
Sasisho la Mwisho Liliwasilishwa:	03/24/2019
Sasisho la Mwisho Lilichapishwa:	04/15/2019
Tarehe ya matokeo ya kwanza yaliyowasilishwa:	02/26/2019
Tarehe ya matokeo ya kwanza ya QC yaliyowasilishwa:	03/24/2019
Tarehe ya matokeo ya kwanza kuchapishwa:	04/15/2019
Tarehe halisi ya kuanza kwa masomo:	10/31/2015
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	03/08/2018
Tarehe ya Kukamilisha Utafiti:	03/08/2018

Hali au ugonjwa

Intrinsic Aging of Skin

Uingiliaji / matibabu

Drug: Older Group Ages 55-75

Awamu

Awamu 4

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Other: Older Group Ages 55-75 Active and Placebo. Participants received retinol lotion on one arm and placebo to match on the other arm.	Drug: Older Group Ages 55-75 Retinol in the form of vitamin A lotion
No Intervention: Young Group Ages 18-25 Participants in the group will give tissue sample only for comparison.

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Years Kwa 18 Years
Jinsia Inastahiki Kujifunza	Female
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - able to provide written informed consent - older group: age between 50 and 75 years - young group: age 18 to 25 years - all four grandparents of Han Chinese, Japanese, Korean descent - body mass index within normal or overweight range - no history of weight loss of >20 lbs within past 5 years Exclusion Criteria: - skin condition in the areas of skin biopsy that would obscure results of analysis - topical creams or treatment to arms 2 weeks prior to study baseline visit - individuals with known hypersensitivity to retinoid class of agents (older group only) - prior anti-aging treatments to arms including retinol, microdermabrasion within 2 weeks of baseline visit - prior laser therapy or surgical procedure to arms - prior radiation or other trauma (extensive burns or abrasions) to arm skin - hormone-based therapy within 4 weeks of enrollment

Matokeo

Hatua za Matokeo ya Msingi

1. Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) [Week 12]

Differences in transcript levels are reported as the number that were upregulated or downregulated in the participant's retinol-treated arm versus their placebo-treated arm.

2. Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline) [Week 1]

Differences in transcript levels are reported as the number of genes that were upregulated or downregulated in the Younger Group participant tissue samples, as compared to a baseline provided by tissue samples collected from the Older Group (prior to their treatment).

Hatua za Matokeo ya Sekondari

1. Transepidermal Water Loss [Baseline; Week 12]

Transepidermal Water Loss of arm skin was measured in units of grams/hours/meters squared.

2. Severity of Arm Skin Wrinkling [Baseline; Week 12]

Wrinkling was assessed by the investigator using a 10-point Likert scale (range 0 to 9, lower scores correspond to less wrinkling).

3. Elasticity on Arm Skin [Baseline; week 12]

Elasticity was assessed using cutometry (R2 curve) as millimeters per second

4. Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events [Baseline through week 12]

Skin and subcutaneous adverse events were assessed for this outcome and documented and scored according to CTCAE version 4.03.