Role of Oxygen for Vascular Dysfunction

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Ingia / Ingia

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HaliImekamilika

Wadhamini

Klinik für Kardiologie, Pneumologie und Angiologie

JARIBIO LA KLINIKI: NCT02127333

BioSeek: nct02127333

Maneno muhimu

hypoxia

Kikemikali

Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.

Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.

We hypothesize that hypoxemia leads to impaired vascular function.

Tarehe

Imethibitishwa Mwisho:	11/30/2014
Iliyowasilishwa Kwanza:	04/28/2014
Uandikishaji uliokadiriwa Uliwasilishwa:	04/28/2014
Iliyotumwa Kwanza:	04/29/2014
Sasisho la Mwisho Liliwasilishwa:	12/13/2014
Sasisho la Mwisho Lilichapishwa:	12/15/2014
Tarehe halisi ya kuanza kwa masomo:	12/31/2010
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	08/31/2013
Tarehe ya Kukamilisha Utafiti:	08/31/2013

Hali au ugonjwa

Endothelial Dysfunction

FMD

IMT

Microcirculation

Oxygen Pressure

Carbon Dioxide Pressure

Oxygen Saturation

Forced Expiratory Volume After 1 Second

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
CAD patients with COPD
CAD patients without COPD
healthy volunteers

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	40 Years Kwa 40 Years
Jinsia Inastahiki Kujifunza	Male
Njia ya sampuli	Non-Probability Sample
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - stable coronary artery disease - stable chronic obstructive pulmonary disease Exclusion Criteria: - acute myocardial infarction within 30 days - acute exacerbated COPD within 30 days - acute infections - severe acute or chronic renal failure - severe heart failure - atrial fibrillation - severe cardiac arrhythmia - hypotension - active malignant disease - active rheumatic disease - pulmonary hypertension with vasoactive therapy

Matokeo

Hatua za Matokeo ya Msingi

1. Flow-mediated dilation of the brachial artery [Baseline]

Hatua za Matokeo ya Sekondari

1. Forearm blood flow [Baseline]

2. Laser doppler perfusion [Baseline]

3. Intima-media thickness of the brachial artery [Baseline]

4. Fractional diameter change of the brachial artery [Baseline]

5. Endothelium-independent vasodilation of the brachial artery [Baseline]

Hatua Nyingine za Matokeo

1. Plasma nitrite concentration [Baseline]