Studies of White Blood Cells Derived From HHT Patients
Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Kiungo kimehifadhiwa kwenye clipboard
HaliInatumika, sio kuajiri
Wadhamini
Imperial College London
Washirika
British Heart Foundation
JARIBIO LA KLINIKI: NCT00230633
BioSeek: nct00230633
Maneno muhimu
Kikemikali
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to take blood samples from patients with HHT, and culture white blood cells that express the proteins mutated in HHT, namely endoglin and ALK-1. We will study the properties of these cells which will involve their growth in media prompting different types of differentiation, or infection of cell lines with Epstein Barr virus to provide cell lines which can be repeatedly studied. It is anticipated that DNA, mRNA and proteins will be extracted from these cells for study of white cell responses and association with expression levels of endoglin and ALK-1 We hypothesize that these cells which express "half-normal" endoglin or ALK-1 will show altered protein synthetic differences when compared to normal white blood cells. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.
Tarehe
Imethibitishwa Mwisho: | 09/30/2019 |
Iliyowasilishwa Kwanza: | 09/28/2005 |
Uandikishaji uliokadiriwa Uliwasilishwa: | 09/28/2005 |
Iliyotumwa Kwanza: | 10/02/2005 |
Sasisho la Mwisho Liliwasilishwa: | 10/06/2019 |
Sasisho la Mwisho Lilichapishwa: | 10/08/2019 |
Tarehe halisi ya kuanza kwa masomo: | 03/31/2002 |
Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 09/30/2026 |
Tarehe ya Kukamilisha Utafiti: | 09/30/2026 |
Hali au ugonjwa
Telangiectasia, Hereditary Hemorrhagic
Awamu
-
Vigezo vya Kustahiki
Jinsia Inastahiki Kujifunza | All |
Njia ya sampuli | Non-Probability Sample |
Hupokea Wajitolea wa Afya | Ndio |
Vigezo | Inclusion Criteria: - Patients with HHT, - HHT patients family members Exclusion Criteria: - Unable to provide informed consent |
Matokeo
Hatua za Matokeo ya Msingi
1. Proteins and cellular markers related to coagulation [on average completing in 1-5 years]
Not specified at outset. Blood samples will be collected over the recruitment period, usually on a single day. Analyses of biomarkers relate to the SAME DAY, within 24hs, though will be evaluated over subsequent months, on average completing in 1-5 years.