The Physiology of Fatigue in Patients With Chronic Liver Disease
Maneno muhimu
Kikemikali
Maelezo
Fatigue is a common symptom in patients with chronic liver disease, and can severely impact quality of life. Thus far, there is scant knowledge about the causes of fatigue in this population, and almost no specific treatments for fatigue have been found effective in clinical trials. Sleep disturbance and alterations in plasma melatonin profiles have been documented in patients with cirrhosis, but remain largely unstudied in patients with earlier stages of liver disease. Up to 50 patients will be enrolled in a case-control study on the physiology of fatigue in patients with chronic liver disease. This is a descriptive study, exploring the concept that fatigue may be the result of circadian rhythms in the central nervous system being out of sync with circadian rhythms in peripheral organs, i.e. unsynchronized central and peripheral clocks.
Tarehe
| Imethibitishwa Mwisho: | 11/19/2018 |
| Iliyowasilishwa Kwanza: | 05/30/2013 |
| Uandikishaji uliokadiriwa Uliwasilishwa: | 05/30/2013 |
| Iliyotumwa Kwanza: | 06/03/2013 |
| Sasisho la Mwisho Liliwasilishwa: | 11/20/2018 |
| Sasisho la Mwisho Lilichapishwa: | 11/22/2018 |
| Tarehe halisi ya kuanza kwa masomo: | 05/30/2013 |
| Tarehe ya Kukamilisha Msingi iliyokadiriwa: | 09/10/2015 |
| Tarehe ya Kukamilisha Utafiti: | 11/19/2018 |
Hali au ugonjwa
Awamu
Vigezo vya Kustahiki
| Zama zinazostahiki Kujifunza | 18 Years Kwa 18 Years |
| Jinsia Inastahiki Kujifunza | All |
| Hupokea Wajitolea wa Afya | Ndio |
| Vigezo | - INCLUSION CRITERIA: - Adults (age >18) with chronic liver disease of any etiology EXCLUSION CRITERIA: - Treatment with medications or supplements frequently associated with fatigue, such as interferon (within the last four months), beta-blockers, calcium channel blockers, benzodiazepines, sedating antihistamines, antidepressants, antipsychotics, or melatonin. In select instances, patients using these medications may be enrolled if, in the opinion of the investigators, their fatigue is clearly unrelated to the medication. - Untreated or uncontrolled comorbidities that influence fatigue, including thyroid disorders (TSH>5 mcIU/mL), anemia (Hemoglobin<11 g/dL), major depression, active substance abuse or other conditions as determined by the enrolling physician. Comorbidities that are adequately controlled will not exclude patients. - Untreated sleep disorders such as obstructive sleep apnea or restless leg syndrome - Decompensated cirrhosis (encephalopathy, gastrointestinal bleeding, ascites, bilirubin >2) within the last six months - Patients planning to travel outside the time zone during the study period - Known or suspected significant gastrointestinal motility disorder, obstruction, or structuring disease - Pregnancy, breastfeeding, or intention to become pregnant - Inability to provide informed consent |
Matokeo
Hatua za Matokeo ya Msingi
1. Circadian rythms [2-7 days]
